Found 10 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 1' and Ligand = 'BDBM17660' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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Patents
Similars
| PDB Article PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche
Curated by PDSP Ki Database
| |
J Neurochem 75: 2590-601 (2000)
Article DOI: 10.1046/j.1471-4159.2000.0752590.x BindingDB Entry DOI: 10.7270/Q2J67FGZ |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(RAT) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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Patents
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| PDB PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parc Club Orsay Universit£
Curated by ChEMBL
| Assay Description Binding affinity at Metabotropic glutamate receptor 1 |
J Med Chem 45: 3171-83 (2002)
BindingDB Entry DOI: 10.7270/Q2B27W18 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNS Research
Curated by PDSP Ki Database
| |
J Neurochem 67: 58-63 (1996)
Article DOI: 10.1046/j.1471-4159.1996.67010058.x BindingDB Entry DOI: 10.7270/Q2P55M1B |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by PDSP Ki Database
| |
Annu Rev Pharmacol Toxicol 37: 205-37 (1997)
Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Agonist potency against cloned human metabotropic glutamate receptor 1 |
J Med Chem 43: 2609-45 (2000)
BindingDB Entry DOI: 10.7270/Q2DZ090Q |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(RAT) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB PubMed
| n/a | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a |
CNS Research
Curated by ChEMBL
| Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1b in rat |
J Med Chem 38: 1417-26 (1995)
BindingDB Entry DOI: 10.7270/Q20R9Q1R |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(RAT) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| PDB PubMed
| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
CNS Research
Curated by ChEMBL
| Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat |
J Med Chem 38: 1417-26 (1995)
BindingDB Entry DOI: 10.7270/Q20R9Q1R |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(RAT) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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| PDB PubMed
| n/a | n/a | n/a | n/a | 1.64E+4 | n/a | n/a | n/a | n/a |
CNS Research
Curated by ChEMBL
| Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1b in human |
J Med Chem 38: 1417-26 (1995)
BindingDB Entry DOI: 10.7270/Q20R9Q1R |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| PDB Article PubMed
| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description Effective concentration of the compound for half maximal stimulation of PI hydrolysis (mGluR1a) |
J Med Chem 39: 3998-4006 (1996)
Article DOI: 10.1021/jm9601718 BindingDB Entry DOI: 10.7270/Q2765DFJ |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Metabotropic glutamate receptor 1
(RAT) | BDBM17660
![PNG](/data/jpeg/tenK1/BindingDB_17660.png) ((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| PDB PubMed
| n/a | n/a | n/a | n/a | 750 | n/a | n/a | n/a | n/a |
CNS Research
Curated by ChEMBL
| Assay Description Concentration for half maximal activation of metabotropic glutamate mGluR1c in rat |
J Med Chem 38: 1417-26 (1995)
BindingDB Entry DOI: 10.7270/Q20R9Q1R |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |