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Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 11/12/13/14' and Ligand = 'BDBM50122911'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))
BDBM50122911
PNG
(6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...)
Show SMILES Fc1ccc(-c2nc3ccccn3c2C2=NN(C(=O)CC2)c2c(Cl)cccc2Cl)c(Cl)c1 |t:16|
Show InChI InChI=1S/C23H14Cl3FN4O/c24-15-4-3-5-16(25)22(15)31-20(32)10-9-18(29-31)23-21(14-8-7-13(27)12-17(14)26)28-19-6-1-2-11-30(19)23/h1-8,11-12H,9-10H2
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KEGG

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISA


J Med Chem 46: 349-52 (2003)


Article DOI: 10.1021/jm025585h
BindingDB Entry DOI: 10.7270/Q27P8XRR
More data for this
Ligand-Target Pair