BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Oxysterols receptor LXR-beta' and Ligand = 'BDBM26066'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM26066 (2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Binding affinity to recombinant human LXRbeta-LBD expressed in Escherichia coli BL21 (DE3) assessed as inhibitory constant incubated for 30 mins by f...				Eur J Med Chem 178: 458-467 (2019) Article DOI: 10.1016/j.ejmech.2019.06.011 BindingDB Entry DOI: 10.7270/Q2BC42WH
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM26066 (2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of hyodeoxycholicacid-based fluorescent tracer from recombinant human LXRbeta LBD (215 to 461 residues) expressed in Escherichia coli BL...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112240 BindingDB Entry DOI: 10.7270/Q2MG7T4D
TBA					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM26066 (2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
The Rockefeller University US Patent					Assay Description As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...				US Patent US10543183 (2020) BindingDB Entry DOI: 10.7270/Q2JW8H8C
The Rockefeller University US Patent					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM26066 (2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
The Rockefeller University US Patent					Assay Description As used herein, reference to the activity of an LXR agonist at LXRα and LXRβ refer to the activity as measured using the ligand sensing ass...				US Patent US10945978 (2021) BindingDB Entry DOI: 10.7270/Q2959MPZ
The Rockefeller University US Patent					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM26066 (2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Rgenix, Inc. US Patent					Assay Description TBD				US Patent US10669296 (2020) BindingDB Entry DOI: 10.7270/Q2V127W1
Rgenix, Inc. US Patent					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM26066 (2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	900	n/a	n/a	n/a	n/a
Goethe-University Frankfurt Curated by ChEMBL					Assay Description Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferas...				Bioorg Med Chem Lett 27: 1193-1198 (2017) Article DOI: 10.1016/j.bmcl.2017.01.066 BindingDB Entry DOI: 10.7270/Q2668GNW
Goethe-University Frankfurt Curated by ChEMBL					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM26066 (2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.67E+3	n/a	n/a	n/a	n/a
Wyeth Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta ligand binding domain expressed in human HuH7 cells co-transfected with Gal4-DBD by transactivation assay				Bioorg Med Chem Lett 20: 689-93 (2010) Article DOI: 10.1016/j.bmcl.2009.11.062 BindingDB Entry DOI: 10.7270/Q2W66KV8
Wyeth Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair