BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Peroxisome proliferator-activated receptor alpha' and Ligand = 'BDBM21753'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM21753 (2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human GAL4 fused PPARalpha-LBD expressed in human HepG2 cells after 18 hrs by luciferase reporter gene assay				Eur J Med Chem 159: 267-276 (2018) Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM21753 (2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	7.4	22
Bayer HealthCare Pharmaceuticals Corporation					Assay Description Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...				J Med Chem 50: 984-1000 (2007) Article DOI: 10.1021/jm061299k BindingDB Entry DOI: 10.7270/Q2NK3C93
Bayer HealthCare Pharmaceuticals Corporation					More data for this Ligand-Target Pair