Found 2 hits Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase tankyrase-2' and Ligand = 'BDBM50579981' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50579981
(CHEMBL5071436 | US11926614, Example 193)Show SMILES Fc1ccccc1-n1c(nnc1-c1ccccn1)[C@H]1C[C@@H](C1)NC(=O)c1cccc2nccnc12 |r,wU:20.25,wD:18.20,(66.64,-7.99,;66.03,-9.38,;66.93,-10.61,;66.31,-12.01,;64.8,-12.17,;63.9,-10.94,;64.53,-9.55,;63.63,-8.31,;64.11,-6.84,;62.86,-5.93,;61.61,-6.84,;62.09,-8.31,;61.19,-9.54,;61.81,-10.93,;60.92,-12.16,;59.4,-12,;58.78,-10.61,;59.67,-9.38,;65.58,-6.36,;66.95,-7.07,;67.66,-5.69,;66.28,-4.99,;69.13,-5.22,;69.46,-3.71,;68.3,-2.67,;70.93,-3.22,;71.24,-1.71,;72.7,-1.23,;73.86,-2.26,;73.54,-3.78,;74.68,-4.8,;74.37,-6.31,;72.89,-6.79,;71.75,-5.76,;72.07,-4.25,)| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50579981
(CHEMBL5071436 | US11926614, Example 193)Show SMILES Fc1ccccc1-n1c(nnc1-c1ccccn1)[C@H]1C[C@@H](C1)NC(=O)c1cccc2nccnc12 |r,wU:20.25,wD:18.20,(66.64,-7.99,;66.03,-9.38,;66.93,-10.61,;66.31,-12.01,;64.8,-12.17,;63.9,-10.94,;64.53,-9.55,;63.63,-8.31,;64.11,-6.84,;62.86,-5.93,;61.61,-6.84,;62.09,-8.31,;61.19,-9.54,;61.81,-10.93,;60.92,-12.16,;59.4,-12,;58.78,-10.61,;59.67,-9.38,;65.58,-6.36,;66.95,-7.07,;67.66,-5.69,;66.28,-4.99,;69.13,-5.22,;69.46,-3.71,;68.3,-2.67,;70.93,-3.22,;71.24,-1.71,;72.7,-1.23,;73.86,-2.26,;73.54,-3.78,;74.68,-4.8,;74.37,-6.31,;72.89,-6.79,;71.75,-5.76,;72.07,-4.25,)| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human TNKS2 (873 to 1162 residues) incubated for 20 hrs in presence of NAD |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01264
BindingDB Entry DOI: 10.7270/Q21R6VDH |
More data for this
Ligand-Target Pair | |
Search and Browse
