Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene Wnt-1' and Ligand = 'BDBM385067'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM385067 (US10287267, Compound 1085 | US10287267, Compound 7...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCNCC3)cc2c1 Show InChI InChI=1S/C19H21N5O/c1-24-12-17(11-22-24)14-2-3-15-10-21-18(9-16(15)8-14)23-19(25)13-4-6-20-7-5-13/h2-3,8-13,20H,4-7H2,1H3,(H,21,23,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	920	n/a	n/a	n/a	n/a
Novartis					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2MS3W3C
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM385067 (US10287267, Compound 1085 | US10287267, Compound 7...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCNCC3)cc2c1 Show InChI InChI=1S/C19H21N5O/c1-24-12-17(11-22-24)14-2-3-15-10-21-18(9-16(15)8-14)23-19(25)13-4-6-20-7-5-13/h2-3,8-13,20H,4-7H2,1H3,(H,21,23,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...				US Patent US10508099 (2019) BindingDB Entry DOI: 10.7270/Q2DJ5J0C
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM385067 (US10287267, Compound 1085 | US10287267, Compound 7...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCNCC3)cc2c1 Show InChI InChI=1S/C19H21N5O/c1-24-12-17(11-22-24)14-2-3-15-10-21-18(9-16(15)8-14)23-19(25)13-4-6-20-7-5-13/h2-3,8-13,20H,4-7H2,1H3,(H,21,23,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	920	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...				US Patent US10508099 (2019) BindingDB Entry DOI: 10.7270/Q2DJ5J0C
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM385067 (US10287267, Compound 1085 | US10287267, Compound 7...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCNCC3)cc2c1 Show InChI InChI=1S/C19H21N5O/c1-24-12-17(11-22-24)14-2-3-15-10-21-18(9-16(15)8-14)23-19(25)13-4-6-20-7-5-13/h2-3,8-13,20H,4-7H2,1H3,(H,21,23,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a
Novartis					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				J Med Chem 51: 7049-52 (2008) BindingDB Entry DOI: 10.7270/Q2MS3W3C
					More data for this Ligand-Target Pair