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Found 2 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene Wnt-1' and Ligand = 'BDBM385369'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM385369
PNG
(US10287267, Compound 1079 | US10508099, Compound 1...)
Show SMILES CC(C)CN1CCCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C24H31N5O/c1-17(2)15-29-9-4-5-18(8-10-29)24(30)27-23-12-21-11-19(6-7-20(21)13-25-23)22-14-26-28(3)16-22/h6-7,11-14,16-18H,4-5,8-10,15H2,1-3H3,(H,25,27,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.43E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...

US Patent US10508099 (2019)


BindingDB Entry DOI: 10.7270/Q2DJ5J0C
More data for this
Ligand-Target Pair
Proto-oncogene Wnt-1


(Homo sapiens (human))		BDBM385369
PNG
(US10287267, Compound 1079 | US10508099, Compound 1...)
Show SMILES CC(C)CN1CCCC(CC1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C24H31N5O/c1-17(2)15-29-9-4-5-18(8-10-29)24(30)27-23-12-21-11-19(6-7-20(21)13-25-23)22-14-26-28(3)16-22/h6-7,11-14,16-18H,4-5,8-10,15H2,1-3H3,(H,25,27,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.43E+3n/an/an/an/a



Novartis



Assay Description
The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...

J Med Chem 51: 7049-52 (2008)


BindingDB Entry DOI: 10.7270/Q2MS3W3C
More data for this
Ligand-Target Pair