Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM176544 (US9688710, 104 2,2-dimethyl-3-((4-(4-(2-methyl-5-(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Lexicon Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human HA-tagged SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake measured after 1 to 2 hrs by scintillation cou... | J Med Chem 60: 710-721 (2017) Article DOI: 10.1021/acs.jmedchem.6b01541 BindingDB Entry DOI: 10.7270/Q2C24ZQ7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM176544 (US9688710, 104 2,2-dimethyl-3-((4-(4-(2-methyl-5-(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Lexicon Pharmaceuticals, Inc. US Patent | Assay Description Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co... | US Patent US9688710 (2017) BindingDB Entry DOI: 10.7270/Q2154F7P | |||||||||||
More data for this Ligand-Target Pair |