Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Taiwan University | Assay Description The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated... | J Med Chem 51: 2795-806 (2008) Article DOI: 10.1021/jm701270n BindingDB Entry DOI: 10.7270/Q2B27SK6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse--Intramural Research Program Curated by ChEMBL | Assay Description Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement. | J Med Chem 47: 3388-98 (2004) Article DOI: 10.1021/jm030646c BindingDB Entry DOI: 10.7270/Q2WS8TZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Heights Curated by ChEMBL | Assay Description Displacement of [125I]RTI55 from DAT in rat brain synaptosomes | Bioorg Med Chem 15: 1146-59 (2006) Article DOI: 10.1016/j.bmc.2006.09.070 BindingDB Entry DOI: 10.7270/Q2M61JXC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK Curated by ChEMBL | Assay Description Binding affinity of the compound towards dopamine transporter (DAT) | Bioorg Med Chem Lett 13: 1385-9 (2003) BindingDB Entry DOI: 10.7270/Q2VX0FV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat. | J Med Chem 42: 5029-42 (2000) BindingDB Entry DOI: 10.7270/Q2R49PZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lundbeck AIS Curated by PDSP Ki Database | J Neurochem 44: 1615-22 (1985) Article DOI: 10.1111/j.1471-4159.1985.tb08803.x BindingDB Entry DOI: 10.7270/Q27H1H2F | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55 | J Med Chem 40: 705-16 (1997) Article DOI: 10.1021/jm9606599 BindingDB Entry DOI: 10.7270/Q2XD10ST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Reuptake inhibition was determined at the dopamine transporter labeled with radioligand [3H]-dopamine in nonstandard conditions on brain membranes ob... | J Med Chem 40: 705-16 (1997) Article DOI: 10.1021/jm9606599 BindingDB Entry DOI: 10.7270/Q2XD10ST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55 in nonstandard conditions | J Med Chem 40: 705-16 (1997) Article DOI: 10.1021/jm9606599 BindingDB Entry DOI: 10.7270/Q2XD10ST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-dopamine on synaptosomes obtained from rat caudate. | J Med Chem 40: 705-16 (1997) Article DOI: 10.1021/jm9606599 BindingDB Entry DOI: 10.7270/Q2XD10ST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Reuptake inhibition of [3H]-labeled dopamine (DA) in rat. | J Med Chem 42: 5029-42 (2000) BindingDB Entry DOI: 10.7270/Q2R49PZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 576 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum. | J Med Chem 40: 705-16 (1997) Article DOI: 10.1021/jm9606599 BindingDB Entry DOI: 10.7270/Q2XD10ST | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a |
Universit£ di Perugia Curated by ChEMBL | Assay Description Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cells | J Med Chem 45: 1577-84 (2002) Article DOI: 10.1021/jm011007+ BindingDB Entry DOI: 10.7270/Q29026JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a |
Universit£ di Perugia Curated by ChEMBL | Assay Description Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cells | J Med Chem 45: 1577-84 (2002) Article DOI: 10.1021/jm011007+ BindingDB Entry DOI: 10.7270/Q29026JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM22199 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 7.76 | n/a | n/a | n/a | n/a | n/a |
Universit£ di Perugia Curated by ChEMBL | Assay Description Inhibition of radioligand [125I]RTI-55 binding to human Dopamine transporter in clonal cells | J Med Chem 45: 1577-84 (2002) Article DOI: 10.1021/jm011007+ BindingDB Entry DOI: 10.7270/Q29026JT | |||||||||||
More data for this Ligand-Target Pair |