Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of thromboxane synthase from human platelets. | J Med Chem 29: 1637-43 (1986) BindingDB Entry DOI: 10.7270/Q2WQ02S2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of TXA2 synthetase from human platelets | J Med Chem 29: 342-6 (1986) BindingDB Entry DOI: 10.7270/Q2W66JSZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of thromboxane TXA2 synthetase from human platelets | J Med Chem 29: 1643-50 (1986) BindingDB Entry DOI: 10.7270/Q2C8289W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against thromboxane A2 synthetase | J Med Chem 28: 1427-32 (1985) BindingDB Entry DOI: 10.7270/Q2DJ5DN7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against human thromboxane synthetase | J Med Chem 24: 1139-48 (1982) BindingDB Entry DOI: 10.7270/Q2KK9CB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
CIBA-GEIGY Corporation Curated by ChEMBL | Assay Description Compound was evaluated in vitro for the inhibition of Thromboxane synthase using [14C]-arachidonic acid as radioligand | J Med Chem 34: 1790-7 (1991) BindingDB Entry DOI: 10.7270/Q2BR8R47 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
ZENECA Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibitory activity against human microsomal thromboxane synthase. | J Med Chem 38: 1608-28 (1995) BindingDB Entry DOI: 10.7270/Q2319TWW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Rattus norvegicus) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of thromboxane A2 synthetase | J Med Chem 32: 1265-72 (1989) BindingDB Entry DOI: 10.7270/Q2FF3RBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of platelet microsomal thromboxane A2 synthetase in rabbits | J Med Chem 32: 1265-72 (1989) BindingDB Entry DOI: 10.7270/Q2FF3RBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Rattus norvegicus) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical Research Division of American Cyanamid Company Curated by ChEMBL | Assay Description Tested for inhibition of thromboxane synthetase from spontaneously hypertensive rats | J Med Chem 30: 2277-83 (1988) BindingDB Entry DOI: 10.7270/Q23T9HT6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human platelet thromboxane synthase (TXA2) was determined in human platelets | J Med Chem 30: 185-93 (1987) BindingDB Entry DOI: 10.7270/Q2222VBH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Research Center Curated by ChEMBL | Assay Description Inhibitory activity of the compound to inhibit Inophore-induced arachidonic acid metabolism (inhibition of TXB2 formation) in rat | J Med Chem 32: 1842-60 (1989) BindingDB Entry DOI: 10.7270/Q28W3C8B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of platelet microsomal thromboxane A synthetase in humans | J Med Chem 32: 1265-72 (1989) BindingDB Entry DOI: 10.7270/Q2FF3RBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat des Saarlandes | Assay Description Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and... | J Med Chem 43: 1841-51 (2000) Article DOI: 10.1021/jm991180u BindingDB Entry DOI: 10.7270/Q2D21VTH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of the Saarland Curated by ChEMBL | Assay Description Inhibition of thromboxane synthase P450 TXA2 | J Med Chem 43: 4437-45 (2000) BindingDB Entry DOI: 10.7270/Q25H7FH3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Rattus norvegicus) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Farmitalia Carlo Erba Curated by ChEMBL | Assay Description In vitro inhibition of thromboxane B2 production in rat whole blood. | J Med Chem 36: 2964-72 (1993) BindingDB Entry DOI: 10.7270/Q22R3S9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for inhibitory activity against intact human platelet TXA2 formation | J Med Chem 30: 1588-95 (1987) BindingDB Entry DOI: 10.7270/Q20R9NDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development Curated by ChEMBL | Assay Description Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma. | J Med Chem 30: 1812-8 (1987) BindingDB Entry DOI: 10.7270/Q2ZP454K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Rattus norvegicus) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of thromboxane formation at a concentration of 10e -6 M. | J Med Chem 30: 1036-40 (1987) BindingDB Entry DOI: 10.7270/Q24F1PRV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Rattus norvegicus) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against thromboxane synthetase | J Med Chem 29: 523-30 (1986) BindingDB Entry DOI: 10.7270/Q27W6B6V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Rattus norvegicus) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for the inhibition of thromboxane formation (thromboxane synthetase) in platelets at a concentration of 10e-4 M | J Med Chem 29: 816-9 (1986) BindingDB Entry DOI: 10.7270/Q2H70GCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thromboxane-A synthase (Homo sapiens (Human)) | BDBM7962![]() (4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research UK Curated by ChEMBL | Assay Description Inhibition of Thromboxane A2 synthase after oral administration of 0.03 mmol/kg | J Med Chem 33: 646-52 (1990) BindingDB Entry DOI: 10.7270/Q25X29HP | |||||||||||
More data for this Ligand-Target Pair |