Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 2.12E+3 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR7 expressed in NFkappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by rep... | J Med Chem 53: 4450-65 (2010) Article DOI: 10.1021/jm100358c BindingDB Entry DOI: 10.7270/Q2Q52PS6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.21E+4 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as... | ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Agonist activity at human TLR7 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assay | ACS Med Chem Lett 8: 1148-1152 (2017) Article DOI: 10.1021/acsmedchemlett.7b00256 BindingDB Entry DOI: 10.7270/Q2PV6NW7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB | n/a | n/a | n/a | n/a | 2.21E+3 | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at serotonin 5HT2A receptor assessed as effect on 5HT-induced isometric contractile force in isolated rings of pig coronary arter... | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a |
University of Ljubljana Curated by ChEMBL | Assay Description Agonist activity at human TLR7 in HEK293 cells cotransfected with SEAP reporter gene assessed as activity of SEAP incubated for 24 hrs by quanti-blue... | Eur J Med Chem 179: 109-122 (2019) Article DOI: 10.1016/j.ejmech.2019.06.030 BindingDB Entry DOI: 10.7270/Q2HM5CS7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP r... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126788 BindingDB Entry DOI: 10.7270/Q2FR014F | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay | J Med Chem 57: 339-47 (2014) Article DOI: 10.1021/jm4004957 BindingDB Entry DOI: 10.7270/Q20Z767J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |