BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Toll-like receptor 7' and Ligand = 'BDBM50240849'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR7 expressed in NFkappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by rep...				J Med Chem 53: 4450-65 (2010) Article DOI: 10.1021/jm100358c BindingDB Entry DOI: 10.7270/Q2Q52PS6
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.21E+4	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...				ACS Med Chem Lett 3: 501-504 (2012) Article DOI: 10.1021/ml300079e BindingDB Entry DOI: 10.7270/Q2FB544F
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Agonist activity at human TLR7 expressed in HEK cells after 8 to 12 hrs by NFkappaB/SEAP reporter gene assay				ACS Med Chem Lett 8: 1148-1152 (2017) Article DOI: 10.1021/acsmedchemlett.7b00256 BindingDB Entry DOI: 10.7270/Q2PV6NW7
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at serotonin 5HT2A receptor assessed as effect on 5HT-induced isometric contractile force in isolated rings of pig coronary arter...				Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a
University of Ljubljana Curated by ChEMBL					Assay Description Agonist activity at human TLR7 in HEK293 cells cotransfected with SEAP reporter gene assessed as activity of SEAP incubated for 24 hrs by quanti-blue...				Eur J Med Chem 179: 109-122 (2019) Article DOI: 10.1016/j.ejmech.2019.06.030 BindingDB Entry DOI: 10.7270/Q2HM5CS7
University of Ljubljana Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR7 expressed in HEK-Blue cells assessed as induction of NFkappaB activation by measuring increase in SEAP level by SEAP r...				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126788 BindingDB Entry DOI: 10.7270/Q2FR014F
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50240849 (1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...) Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.07E+4	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay				J Med Chem 57: 339-47 (2014) Article DOI: 10.1021/jm4004957 BindingDB Entry DOI: 10.7270/Q20Z767J
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)