Found 6 hits Enz. Inhib. hit(s) with Target = 'Trace amine-associated receptor 1' and Ligand = 'BDBM50359505' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Trace amine-associated receptor 1
(Mus musculus (Mouse)) | BDBM50359505
(CHEMBL1182312)Show InChI InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 189 | n/a | n/a | n/a | n/a |
University of Pisa
Curated by ChEMBL
| Assay Description Agonist activity at mouse TAAR1 expressed in HEK293 cells coexpressing cAMP BRET biosensor assessed as induction of CAMP production after 20 mins by ... |
J Med Chem 58: 5096-107 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00526 BindingDB Entry DOI: 10.7270/Q2PC3446 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Trace amine-associated receptor 1
(Rattus norvegicus (Rat)) | BDBM50359505
(CHEMBL1182312)Show InChI InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 22.4 | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by... |
Bioorg Med Chem 19: 7044-8 (2011)
Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Trace amine-associated receptor 1
(Homo sapiens (Human)) | BDBM50359505
(CHEMBL1182312)Show InChI InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 225 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at recombinant human TAAR1 expressed in CHO-K1 cells assessed as increase in intracellular cAMP incubated for 30 mins by HTRF analys... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.1c00527 BindingDB Entry DOI: 10.7270/Q25X2DSH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Trace amine-associated receptor 1
(Homo sapiens (Human)) | BDBM50359505
(CHEMBL1182312)Show InChI InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.69E+3 | n/a | n/a | n/a | n/a |
University of Genoa
Curated by ChEMBL
| Assay Description Inhibition of full length recombinant human N-terminal HA-tagged/C-terminal FLAG-tagged TAAR1 expressed in CHOK1 cells assessed as increase in cAMP a... |
Eur J Med Chem 127: 781-792 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.058 BindingDB Entry DOI: 10.7270/Q2C24ZPS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Trace amine-associated receptor 1
(Mus musculus (Mouse)) | BDBM50359505
(CHEMBL1182312)Show InChI InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | n/a | n/a | 189 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at mouse TAAR1 |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2QZ2FNF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Trace amine-associated receptor 1
(Homo sapiens (Human)) | BDBM50359505
(CHEMBL1182312)Show InChI InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a |
Research Triangle Institute
Curated by ChEMBL
| Assay Description Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins usi... |
Bioorg Med Chem 19: 7044-8 (2011)
Article DOI: 10.1016/j.bmc.2011.10.007 BindingDB Entry DOI: 10.7270/Q2765FR0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |