Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50266285 (CHEMBL4086276) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center and Research Institute Curated by ChEMBL | Assay Description Inhibition of recombinant human TAF1 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assay | J Med Chem 60: 157-169 (2017) Article DOI: 10.1021/acs.jmedchem.6b00923 BindingDB Entry DOI: 10.7270/Q2TM7DMZ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50266285 (CHEMBL4086276) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to TAF1 in HEK293T cells assessed as increase in TAF1 level by ITDR analysis | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50266285 (CHEMBL4086276) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50266285 (CHEMBL4086276) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human TAF1 tandem bromodomain (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constan... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50266285 (CHEMBL4086276) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human TAF1 BD 1 (1373 to 1499 residues) transfected in Escherichia coli BL21 (DE3) by isothermal titration calorimetric analysis | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50266285 (CHEMBL4086276) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to human TAF1 BD 2 (1501 to 1635 residues) transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant by isotherma... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01999 BindingDB Entry DOI: 10.7270/Q2J96B94 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |