BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Tyrosinase' and Ligand = 'BDBM50205807'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosinase (Homo sapiens (Human))	BDBM50205807 (CHEMBL3978212) Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...				J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967 BindingDB Entry DOI: 10.7270/Q2CN77C2
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50205807 (CHEMBL3978212) Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Competitive inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by double-reciprocal plo...				J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967 BindingDB Entry DOI: 10.7270/Q2CN77C2
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50205807 (CHEMBL3978212) Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Grenoble-Alpes/CNRS Curated by ChEMBL					Assay Description Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ...				ACS Med Chem Lett 8: 55-60 (2017) Article DOI: 10.1021/acsmedchemlett.6b00369 BindingDB Entry DOI: 10.7270/Q24F1SQN
Univ. Grenoble-Alpes/CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50205807 (CHEMBL3978212) Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
King Khalid University Curated by ChEMBL					Assay Description Inhibition of tyrosinase (unknown origin)				Eur J Med Chem 166: 417-431 (2019) Article DOI: 10.1016/j.ejmech.2019.01.078 BindingDB Entry DOI: 10.7270/Q2ZW1QF5
King Khalid University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50205807 (CHEMBL3978212) Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Grenoble-Alpes/CNRS Curated by ChEMBL					Assay Description Inhibition of tyrosinase in human MNT1 cell lysate pretreated prior to addition of L-DOPA as substrate measured after 3 hrs				ACS Med Chem Lett 8: 55-60 (2017) Article DOI: 10.1021/acsmedchemlett.6b00369 BindingDB Entry DOI: 10.7270/Q24F1SQN
Univ. Grenoble-Alpes/CNRS Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50205807 (CHEMBL3978212) Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by spectrophotometric analysis				J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967 BindingDB Entry DOI: 10.7270/Q2CN77C2
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50205807 (CHEMBL3978212) Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.66E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells using L-DOPA as substrate by spectrophotometric analysis				J Med Chem 61: 7395-7418 (2018) Article DOI: 10.1021/acs.jmedchem.7b00967 BindingDB Entry DOI: 10.7270/Q2CN77C2
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosinase (Homo sapiens (Human))	BDBM50205807 (CHEMBL3978212) Show SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1 Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
Univ. Grenoble-Alpes/CNRS Curated by ChEMBL					Assay Description Inhibition of tyrosinase in human MNT1 cells assessed as suppression of melanin biosynthesis measured after 96 hrs				ACS Med Chem Lett 8: 55-60 (2017) Article DOI: 10.1021/acsmedchemlett.6b00369 BindingDB Entry DOI: 10.7270/Q24F1SQN
Univ. Grenoble-Alpes/CNRS Curated by ChEMBL					More data for this Ligand-Target Pair