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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ITK/TSK [357-620,Y512E]' and Ligand = 'BDBM213215'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase ITK/TSK [357-620,Y512E]


(Homo sapiens (Human))		BDBM213215
PNG
(N-(cis-2-{[4-(4-Morpholinylmethyl)-6-([1,3]thiazol...)
Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1Nc1nc(CN2CCOCC2)cc(Nc2nc3cccnc3s2)n1 |r|
Show InChI InChI=1S/C24H30N8O2S/c1-2-21(33)27-17-6-3-4-7-18(17)28-23-26-16(15-32-10-12-34-13-11-32)14-20(30-23)31-24-29-19-8-5-9-25-22(19)35-24/h2,5,8-9,14,17-18H,1,3-4,6-7,10-13,15H2,(H,27,33)(H2,26,28,29,30,31)/t17-,18+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 320n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...

J Biol Chem 288: 28195-206 (2013)


Article DOI: 10.1074/jbc.M113.474114
BindingDB Entry DOI: 10.7270/Q2ZW1JSK
More data for this
Ligand-Target Pair