BDBM213215 N-(cis-2-{[4-(4-Morpholinylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyrimidinyl]amino}cyclohexyl)-2-propenamide (4)

SMILES: C=CC(=O)N[C@H]1CCCC[C@H]1Nc1nc(CN2CCOCC2)cc(Nc2nc3cccnc3s2)n1

InChI Key: InChIKey=GAAVILUSXJEKDO-ZWKOTPCHSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 213215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interlukin-2-inducible tyrosine kinase (Itk) (Homo sapiens (Human))	BDBM213215 (N-(cis-2-{[4-(4-Morpholinylmethyl)-6-([1,3]thiazol...) Show SMILES C=CC(=O)N[C@H]1CCCC[C@H]1Nc1nc(CN2CCOCC2)cc(Nc2nc3cccnc3s2)n1 |r| Show InChI InChI=1S/C24H30N8O2S/c1-2-21(33)27-17-6-3-4-7-18(17)28-23-26-16(15-32-10-12-34-13-11-32)14-20(30-23)31-24-29-19-8-5-9-25-22(19)35-24/h2,5,8-9,14,17-18H,1,3-4,6-7,10-13,15H2,(H,27,33)(H2,26,28,29,30,31)/t17-,18+/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...				J Biol Chem 288: 28195-206 (2013) Article DOI: 10.1074/jbc.M113.474114 BindingDB Entry DOI: 10.7270/Q2ZW1JSK
					More data for this Ligand-Target Pair