Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM237878'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM237878 (US9394282, 9-13) Show SMILES NC(=O)c1cn(nc1Nc1ccc(Cl)c(F)c1)[C@@H]1COCC[C@H]1C#N |r| Show InChI InChI=1S/C16H15ClFN5O2/c17-12-2-1-10(5-13(12)18)21-16-11(15(20)24)7-23(22-16)14-8-25-4-3-9(14)6-19/h1-2,5,7,9,14H,3-4,8H2,(H2,20,24)(H,21,22)/t9-,14+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9394282 (2016) BindingDB Entry DOI: 10.7270/Q2J10233
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