Found 7 hits Enz. Inhib. hit(s) with Target = 'Vasopressin V1a receptor' and Ligand = 'BDBM35714' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vasopressin V1a receptor
(Homo sapiens (Human)) | BDBM35714
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12 Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31) | PDB
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| PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Tokushima Institute of New Drug Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 287: 860-7 (1998)
BindingDB Entry DOI: 10.7270/Q2S46QGC |
More data for this
Ligand-Target Pair | |
Vasopressin V1a receptor
(RAT) | BDBM35714
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12 Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31) | UniProtKB/SwissProt
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| PubMed
| 193 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 282: 301-8 (1997)
BindingDB Entry DOI: 10.7270/Q25T3J1N |
More data for this
Ligand-Target Pair | |
Vasopressin V1a receptor
(Homo sapiens (Human)) | BDBM35714
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12 Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31) | PDB
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antibodypedia
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PubMed
| 195 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
UMR7200 CNRS/Universit£ de Strasbourg
Curated by ChEMBL
| Assay Description
Binding affinity to vasopressin V1a receptor |
J Med Chem 55: 8588-602 (2012)
Article DOI: 10.1021/jm3006146
BindingDB Entry DOI: 10.7270/Q28G8MT5 |
More data for this
Ligand-Target Pair | |
Vasopressin V1a receptor
(RAT) | BDBM35714
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12 Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31) | UniProtKB/SwissProt
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| 232 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Co., Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 282: 301-8 (1997)
BindingDB Entry DOI: 10.7270/Q25T3J1N |
More data for this
Ligand-Target Pair | |
Vasopressin V1a receptor
(RAT) | BDBM35714
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12 Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31) | UniProtKB/SwissProt
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| 524 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Second Tokushima Institute of New Drug Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 287: 860-7 (1998)
BindingDB Entry DOI: 10.7270/Q2S46QGC |
More data for this
Ligand-Target Pair | |
Vasopressin V1a receptor
(RAT) | BDBM35714
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12 Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31) | UniProtKB/SwissProt
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| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Otsuka Pharmaceutical Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AVP from AVP-V1a receptor binding site in rat liver |
J Med Chem 39: 3547-55 (1996)
Article DOI: 10.1021/jm960133o
BindingDB Entry DOI: 10.7270/Q2DZ07CT |
More data for this
Ligand-Target Pair | |
Vasopressin V1a receptor
(Homo sapiens (Human)) | BDBM35714
(CHEMBL420762 | Mozavaptan | N-[4-(5-Dimethylamino-...)Show SMILES CN(C)C1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3C)cc2)c2ccccc12 Show InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
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CHEMBL
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| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | 7.4 | 4 |
Otsuka Pharmaceutical Co., Ltd
| Assay Description
After reaching confluence in 12-well or 24-well dishes, the cells were washed twice with ice-cold PBS and incubated for 2 hr with [3H]-AVP at 4 deg C... |
Bioorg Med Chem 7: 1743-54 (1999)
Article DOI: 10.1016/s0968-0896(99)00101-7
BindingDB Entry DOI: 10.7270/Q2W957JR |
More data for this
Ligand-Target Pair | |
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