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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM50248919 ((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | n/a | n/a |
SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD. US Patent | Assay Description The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ... | US Patent US10662189 (2020) BindingDB Entry DOI: 10.7270/Q27D2Z5H | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM50248919 ((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Tetra Discovery Partners, Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein... | J Med Chem 62: 4884-4901 (2019) Article DOI: 10.1021/acs.jmedchem.9b00193 BindingDB Entry DOI: 10.7270/Q26H4MVT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM50248919 ((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Hyderabad Campus Curated by ChEMBL | Assay Description Inhibition of PDE4B (unknown origin) | Eur J Med Chem 174: 198-215 (2019) Article DOI: 10.1016/j.ejmech.2019.04.020 BindingDB Entry DOI: 10.7270/Q2G44TQ6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM50248919 ((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Medicinal Chemistry& Screening ,?Pharmacokinetics& Metabolism , and§Experimental Dermatology , Almirall S.A., Centro de Investigación y Desarrollo , Crta. Laureà Miró 408-410 , Sant Feliu de Curated by ChEMBL | Assay Description Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasma | J Med Chem 61: 2472-2489 (2018) Article DOI: 10.1021/acs.jmedchem.7b01751 BindingDB Entry DOI: 10.7270/Q2HQ42BB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM50248919 ((S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human PDE4B using [3H]cAMP as substrate incubated for 5 mins followed by substrate addition and measured after 10 mins by scintillation... | Citation and Details Article DOI: 10.1016/j.bmc.2016.09.011 BindingDB Entry DOI: 10.7270/Q2N58R28 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
