| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Ligand | BDBM50248919 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2063959 (CHEMBL4719212) |
|---|
| IC50 | 74±n/a nM |
|---|
| Citation |  Balasubramanian, G; Narayanan, S; Andiappan, L; Sappanimuthu, T; Thirunavukkarasu, S; Sundaram, S; Natarajan, S; Sivaraman, N; Rajagopal, S; Nazumudeen, FAA; Saxena, S; Vishwakarma, SL; Narayanan, S; Sharma, GVR; Srinivasan, CV; Kilambi, N In vivo effective dibenzo[b,d]furan-1-yl-thiazoles as novel PDE-4 inhibitors. Bioorg Med Chem24:5702-5716 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 83318.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07343 |
|---|
| Residue: | 736 |
|---|
| Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
|
|
|
|---|
| BDBM50248919 |
|---|
| n/a |
|---|
| Name | BDBM50248919 |
|---|
| Synonyms: | (S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide | APREMILAST | CHEMBL514800 | US10662189, Compound Apremilast |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24N2O7S |
|---|
| Mol. Mass. | 460.5 |
|---|
| SMILES | CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
