BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4D' and Ligand = 'BDBM50299569'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50299569 (3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[2-(2,6...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D expressed in Sf9 cells				J Med Chem 52: 6546-57 (2009) Article DOI: 10.1021/jm900977c BindingDB Entry DOI: 10.7270/Q2N879VV
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50299569 (3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[2-(2,6...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE4D3 expressed in baculovirus system by IMAP assay				J Med Chem 52: 6546-57 (2009) Article DOI: 10.1021/jm900977c BindingDB Entry DOI: 10.7270/Q2N879VV
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50299569 (3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[2-(2,6...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Genoa Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4D3 expressed in baculoviral system				J Med Chem 57: 7061-72 (2014) Article DOI: 10.1021/jm500855w BindingDB Entry DOI: 10.7270/Q23N251C
University of Genoa Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50299569 (3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[2-(2,6...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of C-terminal 6His-tagged human PDE4D3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in 5'-AMP formation using ...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113638 BindingDB Entry DOI: 10.7270/Q2348Q7S
TBA					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50299569 (3-(cyclopentyloxy)-4-methoxybenzaldehyde O-[2-(2,6...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of C-terminal 6His-tagged human PDE4D catalytic domain (244 to 578 residues) expressed in Escherichia coli BL21(DE3) pLysS cells assessed ...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113638 BindingDB Entry DOI: 10.7270/Q2348Q7S
TBA					More data for this Ligand-Target Pair