Found 24 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 50006103 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496943
(CHEMBL3236471)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H17FN4O4S/c1-3-8-29(26,27)23-17-7-5-15(20)18(14(17)10-21)28-12-4-6-16-13(9-12)19(25)24(2)11-22-16/h4-7,9,11,23H,3,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496941
(CHEMBL3236463)Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(Nc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H18ClN5O3S/c1-3-8-29(27,28)24-17-7-5-15(20)18(14(17)10-21)23-12-4-6-16-13(9-12)19(26)25(2)11-22-16/h4-7,9,11,23-24H,3,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496954
(CHEMBL3236470)Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H17ClN4O4S/c1-3-8-29(26,27)23-17-7-5-15(20)18(14(17)10-21)28-12-4-6-16-13(9-12)19(25)24(2)11-22-16/h4-7,9,11,23H,3,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496946
(CHEMBL3236464)Show SMILES CCCS(=O)(=O)Nc1cccc(Nc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H19N5O3S/c1-3-9-28(26,27)23-18-6-4-5-17(15(18)11-20)22-13-7-8-16-14(10-13)19(25)24(2)12-21-16/h4-8,10,12,22-23H,3,9H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496948
(CHEMBL3236472)Show SMILES CCCS(=O)(=O)Nc1cccc(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Show InChI InChI=1S/C19H18N4O4S/c1-3-9-28(25,26)22-17-5-4-6-18(15(17)11-20)27-13-7-8-16-14(10-13)19(24)23(2)12-21-16/h4-8,10,12,22H,3,9H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50430022
(CHEMBL2144069)Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1Nc1ccc2ncn(C)c(=O)c2c1 Show InChI InChI=1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496939
(CHEMBL3236198)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C)c(=O)c3c2)c1Cl Show InChI InChI=1S/C18H18ClFN4O3S/c1-3-8-28(26,27)23-15-7-5-13(20)17(16(15)19)22-11-4-6-14-12(9-11)18(25)24(2)10-21-14/h4-7,9-10,22-23H,3,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496940
(CHEMBL3236459)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(-c4cnn(C)c4)c(=O)c3c2)c1Cl Show InChI InChI=1S/C21H20ClFN6O3S/c1-3-8-33(31,32)27-18-7-5-16(23)20(19(18)22)26-13-4-6-17-15(9-13)21(30)29(12-24-17)14-10-25-28(2)11-14/h4-7,9-12,26-27H,3,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496937
(CHEMBL3233047)Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(N(C)c2ccc3ncn(C)c(=O)c3c2)c1F Show InChI InChI=1S/C19H20ClFN4O3S/c1-4-9-29(27,28)23-16-8-6-14(20)18(17(16)21)25(3)12-5-7-15-13(10-12)19(26)24(2)11-22-15/h5-8,10-11,23H,4,9H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496944
(CHEMBL3236193)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncncc3c2)c1Cl Show InChI InChI=1S/C17H16ClFN4O2S/c1-2-7-26(24,25)23-15-6-4-13(19)17(16(15)18)22-12-3-5-14-11(8-12)9-20-10-21-14/h3-6,8-10,22-23H,2,7H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496942
(CHEMBL3236467)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(N(C)c2ccc3ncn(C)c(=O)c3c2)c1Cl Show InChI InChI=1S/C19H20ClFN4O3S/c1-4-9-29(27,28)23-16-8-6-14(21)18(17(16)20)25(3)12-5-7-15-13(10-12)19(26)24(2)11-22-15/h5-8,10-11,23H,4,9H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496935
(CHEMBL3236196)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncnc(NC)c3c2)c1Cl Show InChI InChI=1S/C18H19ClFN5O2S/c1-3-8-28(26,27)25-15-7-5-13(20)17(16(15)19)24-11-4-6-14-12(9-11)18(21-2)23-10-22-14/h4-7,9-10,24-25H,3,8H2,1-2H3,(H,21,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496952
(CHEMBL3236466)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(N(C)c2ccc3ncn(C)c(=O)c3c2)c1F Show InChI InChI=1S/C19H20F2N4O3S/c1-4-9-29(27,28)23-16-8-6-14(20)18(17(16)21)25(3)12-5-7-15-13(10-12)19(26)24(2)11-22-15/h5-8,10-11,23H,4,9H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496936
(CHEMBL3236462)Show SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(Nc2ccc3ncn(C)c(=O)c3c2)c1F Show InChI InChI=1S/C18H18ClFN4O3S/c1-3-8-28(26,27)23-15-7-5-13(19)17(16(15)20)22-11-4-6-14-12(9-11)18(25)24(2)10-21-14/h4-7,9-10,22-23H,3,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496938
(CHEMBL3236195)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncnc(OC)c3c2)c1Cl Show InChI InChI=1S/C18H18ClFN4O3S/c1-3-8-28(25,26)24-15-7-5-13(20)17(16(15)19)23-11-4-6-14-12(9-11)18(27-2)22-10-21-14/h4-7,9-10,23-24H,3,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496933
(CHEMBL3236460)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(Cc4ccccc4)c(=O)c3c2)c1Cl Show InChI InChI=1S/C24H22ClFN4O3S/c1-2-12-34(32,33)29-21-11-9-19(26)23(22(21)25)28-17-8-10-20-18(13-17)24(31)30(15-27-20)14-16-6-4-3-5-7-16/h3-11,13,15,28-29H,2,12,14H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496951
(CHEMBL3236461)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C)c(=O)c3c2)c1F Show InChI InChI=1S/C18H18F2N4O3S/c1-3-8-28(26,27)23-15-7-5-13(19)17(16(15)20)22-11-4-6-14-12(9-11)18(25)24(2)10-21-14/h4-7,9-10,22-23H,3,8H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496932
(CHEMBL3236194)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3nccnc3c2)c1Cl Show InChI InChI=1S/C17H16ClFN4O2S/c1-2-9-26(24,25)23-14-6-4-12(19)17(16(14)18)22-11-3-5-13-15(10-11)21-8-7-20-13/h3-8,10,22-23H,2,9H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496934
(CHEMBL3236468)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(N(CC)c2ccc3ncn(C)c(=O)c3c2)c1F Show InChI InChI=1S/C20H22F2N4O3S/c1-4-10-30(28,29)24-17-9-7-15(21)19(18(17)22)26(5-2)13-6-8-16-14(11-13)20(27)25(3)12-23-16/h6-9,11-12,24H,4-5,10H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496947
(CHEMBL3236469)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(N(CC)c2ccc3ncn(C)c(=O)c3c2)c1Cl Show InChI InChI=1S/C20H22ClFN4O3S/c1-4-10-30(28,29)24-17-9-7-15(22)19(18(17)21)26(5-2)13-6-8-16-14(11-13)20(27)25(3)12-23-16/h6-9,11-12,24H,4-5,10H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496950
(CHEMBL3236192)Show InChI InChI=1S/C17H16F2N4O2S/c1-2-7-26(24,25)23-15-6-4-13(18)17(16(15)19)22-12-3-5-14-11(8-12)9-20-10-21-14/h3-6,8-10,22-23H,2,7H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496945
(CHEMBL3236197)Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncnc(N(C)C)c3c2)c1Cl Show InChI InChI=1S/C19H21ClFN5O2S/c1-4-9-29(27,28)25-16-8-6-14(21)18(17(16)20)24-12-5-7-15-13(10-12)19(26(2)3)23-11-22-15/h5-8,10-11,24-25H,4,9H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496953
(CHEMBL3236191)Show InChI InChI=1S/C18H17F2N3O2S/c1-2-10-26(24,25)23-16-8-6-14(19)18(17(16)20)22-13-5-7-15-12(11-13)4-3-9-21-15/h3-9,11,22-23H,2,10H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 314 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50496949
(CHEMBL3236465)Show SMILES CCCS(=O)(=O)Nc1ccc(C)c(Nc2ccc3ncn(C)c(=O)c3c2)c1 Show InChI InChI=1S/C19H22N4O3S/c1-4-9-27(25,26)22-15-6-5-13(2)18(11-15)21-14-7-8-17-16(10-14)19(24)23(3)12-20-17/h5-8,10-12,21-22H,4,9H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 851 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of full-length B-Raf V600E mutant (unknown origin) |
Bioorg Med Chem Lett 24: 1923-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.007
BindingDB Entry DOI: 10.7270/Q2Q24368 |
More data for this
Ligand-Target Pair | |
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