BindingDB PrimarySearch

Found 29 hits of ic50 for UniProtKB: P06935
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24732 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6	-11.7	32	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24731 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	9	-11.4	51	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24734 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	11	-11.3	60	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24746 ((2S)-6-amino-N-[(1S)-4-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	13	-11.2	73	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24739 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	19	-10.9	107	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24733 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	20	-10.9	112	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24735 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	26	-10.8	146	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24741 ((2S)-6-amino-N-[(2S)-5-carbamimidamido-1-oxopentan...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	28	-10.7	154	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24736 (Capped tripeptide aldehyde inhibitor, 24 \| benzyl ...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	40	-10.5	222	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24728 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	41	-10.5	231	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair				3D Structure (crystal)
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24744 ((2S)-N-[(1S)-5-amino-1-{[(2S)-5-carbamimidamido-1-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	44	-10.4	245	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24742 ((2S)-6-amino-2-[(2S)-5-amino-2-(1-phenylacetamido)...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	46	-10.4	255	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24737 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	49	-10.4	271	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24748 ((2S)-2-[(2S)-6-amino-2-(1-phenylacetamido)hexanami...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	53	-10.3	297	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24745 ((2S)-6-amino-N-[(1S)-4-carbamimidamido-1-{[(2S)-5-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	58	-10.3	325	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24738 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	81	-10.1	454	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24730 ((2S)-6-amino-2-[(2S)-6-amino-2-[(2E)-3-phenylprop-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	104	-9.90	580	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24743 ((2S)-6-amino-N-[(2S)-5-carbamimidamido-1-oxopentan...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	111	-9.86	619	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24740 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	160	-9.64	891	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33256 (phthalazine-based compound, 7) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33251 (phthalazine-based compound, 2) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33253 (phthalazine-based compound, 4) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20E+3	4.60E+3	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33255 (phthalazine-based compound, 6) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20E+3	7.00E+3	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33254 (phthalazine-based compound, 5) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	1.00E+5	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24747 ((2S)-6-amino-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	2.07E+3	-8.06	1.16E+4	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33257 (phthalazine-based compound, 8) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33252 (phthalazine-based compound, 3) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	9.00E+4	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM33250 (phthalazine-based compound, 1) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.45E+4	2.10E+4	n/a	n/a	n/a	7.5	37
Novartis Institute for Tropical Diseases					Assay Description Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....				Anal Biochem 395: 195-204 (2009) Article DOI: 10.1016/j.ab.2009.08.013 BindingDB Entry DOI: 10.7270/Q2VM49MW
Novartis Institute for Tropical Diseases					More data for this Ligand-Target Pair
Genome polyprotein [1424-1463]/[1502-1685] (West Nile virus (WNV))	BDBM24749 ((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-1-(1H-indol-...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.60E+3	-7.57	2.57E+4	n/a	n/a	n/a	n/a	9.5	37
University of Queensland					Assay Description Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...				J Med Chem 51: 5714-21 (2008) Article DOI: 10.1021/jm800503y BindingDB Entry DOI: 10.7270/Q27P8WPF
University of Queensland					More data for this Ligand-Target Pair