Compile Data Set for Download or QSAR

Found 67 hits of ic50 for UniProtKB: P04637   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374770 (US10246467, Example I-67 | US10246467, Example I-6...) Show SMILES CCOc1cccc(CN2[C@H]3COc4n(nc5cc(ccc45)C(O)=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]22C(=O)Nc3cc(Cl)ccc23)c1 |r| Show InChI InChI=1S/C35H27Cl2FN4O5/c1-2-46-21-6-3-5-18(13-21)16-41-28-17-47-32-22-11-9-19(33(43)44)14-26(22)40-42(32)31(28)29(23-7-4-8-25(37)30(23)38)35(41)24-12-10-20(36)15-27(24)39-34(35)45/h3-15,28-29,31H,2,16-17H2,1H3,(H,39,45)(H,43,44)/t28-,29-,31+,35+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374773 (US10246467, Example I-70 | US10919913, # I-70) Show SMILES CCOc1cccc(CN2[C@H]3COc4n(nc5ccc(cc45)C(O)=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]22C(=O)Nc3cc(Cl)ccc23)c1 |r| Show InChI InChI=1S/C35H27Cl2FN4O5/c1-2-46-21-6-3-5-18(13-21)16-41-28-17-47-32-23-14-19(33(43)44)9-12-26(23)40-42(32)31(28)29(22-7-4-8-25(37)30(22)38)35(41)24-11-10-20(36)15-27(24)39-34(35)45/h3-15,28-29,31H,2,16-17H2,1H3,(H,39,45)(H,43,44)/t28-,29-,31+,35+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374793 (US10246467, Example I-114 | US10246467, Example I-...) Show SMILES OC(=O)c1cnc2nn3[C@@H]4[C@H](COc3c2c1)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C29H22Cl2FN5O4/c30-15-6-7-18-20(9-15)34-28(40)29(18)22(16-2-1-3-19(31)23(16)32)24-21(36(29)11-13-4-5-13)12-41-26-17-8-14(27(38)39)10-33-25(17)35-37(24)26/h1-3,6-10,13,21-22,24H,4-5,11-12H2,(H,34,40)(H,38,39)/t21-,22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374736 (US10246467, Example I-7 | US10246467, Example I-8 ...) Show SMILES COc1cc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2cc1C(O)=O |r| Show InChI InChI=1S/C31H25Cl2FN4O5/c1-42-24-11-17-21(10-18(24)29(39)40)36-38-27-23(13-43-28(17)38)37(12-14-5-6-14)31(25(27)16-3-2-4-20(33)26(16)34)19-8-7-15(32)9-22(19)35-30(31)41/h2-4,7-11,14,23,25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t23-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374730 (US10246467, Example I-1 | US10246467, Example I-2 ...) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C30H23Cl2FN4O4/c31-16-7-9-19-22(11-16)34-29(40)30(19)24(18-2-1-3-20(32)25(18)33)26-23(36(30)12-14-4-5-14)13-41-27-17-8-6-15(28(38)39)10-21(17)35-37(26)27/h1-3,6-11,14,23-24,26H,4-5,12-13H2,(H,34,40)(H,38,39)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374778 (US10246467, Example I-80) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5ccnc(Br)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C29H22BrClFN5O4/c30-25-23(32)17(7-8-33-25)22-24-21(12-41-26-16-5-3-14(27(38)39)9-19(16)35-37(24)26)36(11-13-1-2-13)29(22)18-6-4-15(31)10-20(18)34-28(29)40/h3-10,13,21-22,24H,1-2,11-12H2,(H,34,40)(H,38,39)/t21-,22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374796 (US10246467, Example I-117 | US10919913, # I-117) Show SMILES Cc1cc2nn3[C@@H]4[C@H](CCOc3c2cc1C(O)=O)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C32H27Cl2FN4O4/c1-15-11-23-20(13-19(15)30(40)41)29-39(37-23)28-25(9-10-43-29)38(14-16-5-6-16)32(26(28)18-3-2-4-22(34)27(18)35)21-8-7-17(33)12-24(21)36-31(32)42/h2-4,7-8,11-13,16,25-26,28H,5-6,9-10,14H2,1H3,(H,36,42)(H,40,41)/t25-,26-,28+,32+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374770 (US10246467, Example I-67 | US10246467, Example I-6...) Show SMILES CCOc1cccc(CN2[C@H]3COc4n(nc5cc(ccc45)C(O)=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]22C(=O)Nc3cc(Cl)ccc23)c1 |r| Show InChI InChI=1S/C35H27Cl2FN4O5/c1-2-46-21-6-3-5-18(13-21)16-41-28-17-47-32-22-11-9-19(33(43)44)14-26(22)40-42(32)31(28)29(23-7-4-8-25(37)30(23)38)35(41)24-12-10-20(36)15-27(24)39-34(35)45/h3-15,28-29,31H,2,16-17H2,1H3,(H,39,45)(H,43,44)/t28-,29-,31+,35+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374777 (US10246467, Example I-78 | US10919913, # I-80) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5ccnc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C29H22Cl2FN5O4/c30-15-4-6-18-20(10-15)34-28(40)29(18)22(17-7-8-33-25(31)23(17)32)24-21(36(29)11-13-1-2-13)12-41-26-16-5-3-14(27(38)39)9-19(16)35-37(24)26/h3-10,13,21-22,24H,1-2,11-12H2,(H,34,40)(H,38,39)/t21-,22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374733 (US10246467, Example I-4 | US10246467, Example I-5 ...) Show SMILES OC(=O)c1ccc2nn3[C@@H]4[C@H](COc3c2c1)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C30H23Cl2FN4O4/c31-16-7-8-19-22(11-16)34-29(40)30(19)24(17-2-1-3-20(32)25(17)33)26-23(36(30)12-14-4-5-14)13-41-27-18-10-15(28(38)39)6-9-21(18)35-37(26)27/h1-3,6-11,14,23-24,26H,4-5,12-13H2,(H,34,40)(H,38,39)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374789 (US10246467, Example I-109 | US10246467, Example I-...) Show SMILES Cc1c(ccc2nn3[C@@H]4[C@H](COc3c12)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12)C(O)=O |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c1-14-17(29(39)40)8-10-21-24(14)28-38(36-21)27-23(13-42-28)37(12-15-5-6-15)31(25(27)18-3-2-4-20(33)26(18)34)19-9-7-16(32)11-22(19)35-30(31)41/h2-4,7-11,15,23,25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t23-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374779 (US10246467, Example I-82 | US10919913, # I-82) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cc(Cl)nc(Cl)c5)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C29H22Cl3N5O4/c30-16-4-6-18-20(10-16)33-28(40)29(18)24(15-8-22(31)34-23(32)9-15)25-21(36(29)11-13-1-2-13)12-41-26-17-5-3-14(27(38)39)7-19(17)35-37(25)26/h3-10,13,21,24-25H,1-2,11-12H2,(H,33,40)(H,38,39)/t21-,24-,25+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374733 (US10246467, Example I-4 | US10246467, Example I-5 ...) Show SMILES OC(=O)c1ccc2nn3[C@@H]4[C@H](COc3c2c1)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C30H23Cl2FN4O4/c31-16-7-8-19-22(11-16)34-29(40)30(19)24(17-2-1-3-20(32)25(17)33)26-23(36(30)12-14-4-5-14)13-41-27-18-10-15(28(38)39)6-9-21(18)35-37(26)27/h1-3,6-11,14,23-24,26H,4-5,12-13H2,(H,34,40)(H,38,39)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374730 (US10246467, Example I-1 | US10246467, Example I-2 ...) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C30H23Cl2FN4O4/c31-16-7-9-19-22(11-16)34-29(40)30(19)24(18-2-1-3-20(32)25(18)33)26-23(36(30)12-14-4-5-14)13-41-27-17-8-6-15(28(38)39)10-21(17)35-37(26)27/h1-3,6-11,14,23-24,26H,4-5,12-13H2,(H,34,40)(H,38,39)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374736 (US10246467, Example I-7 | US10246467, Example I-8 ...) Show SMILES COc1cc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2cc1C(O)=O |r| Show InChI InChI=1S/C31H25Cl2FN4O5/c1-42-24-11-17-21(10-18(24)29(39)40)36-38-27-23(13-43-28(17)38)37(12-14-5-6-14)31(25(27)16-3-2-4-20(33)26(16)34)19-8-7-15(32)9-22(19)35-30(31)41/h2-4,7-11,14,23,25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t23-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374750 (US10246467, Example I-32 | US10246467, Example I-3...) Show SMILES CC(C)(C)CN1[C@H]2COc3n(nc4cc(ccc34)C(O)=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H27Cl2FN4O4/c1-30(2,3)14-37-23-13-42-27-17-9-7-15(28(39)40)11-21(17)36-38(27)26(23)24(18-5-4-6-20(33)25(18)34)31(37)19-10-8-16(32)12-22(19)35-29(31)41/h4-12,23-24,26H,13-14H2,1-3H3,(H,35,41)(H,39,40)/t23-,24-,26+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374793 (US10246467, Example I-114 | US10246467, Example I-...) Show SMILES OC(=O)c1cnc2nn3[C@@H]4[C@H](COc3c2c1)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C29H22Cl2FN5O4/c30-15-6-7-18-20(9-15)34-28(40)29(18)22(16-2-1-3-19(31)23(16)32)24-21(36(29)11-13-4-5-13)12-41-26-17-8-14(27(38)39)10-33-25(17)35-37(24)26/h1-3,6-10,13,21-22,24H,4-5,11-12H2,(H,34,40)(H,38,39)/t21-,22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374748 (US10246467, Example I-30 | US10919913, # I-30) Show SMILES C[C@@H]1Oc2n(nc3cc(ccc23)C(O)=O)[C@@H]2[C@H]1N(CC1CC1)[C@]1([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c1-14-26-27(38-28(42-14)18-9-7-16(29(39)40)11-22(18)36-38)24(19-3-2-4-21(33)25(19)34)31(37(26)13-15-5-6-15)20-10-8-17(32)12-23(20)35-30(31)41/h2-4,7-12,14-15,24,26-27H,5-6,13H2,1H3,(H,35,41)(H,39,40)/t14-,24-,26-,27-,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374783 (US10246467, Example I-88 | US10919913, # I-88) Show SMILES OC(=O)c1ccc2nn3[C@@H]4[C@H](CCOc3c2c1)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c32-17-7-8-20-23(13-17)35-30(41)31(20)25(18-2-1-3-21(33)26(18)34)27-24(37(31)14-15-4-5-15)10-11-42-28-19-12-16(29(39)40)6-9-22(19)36-38(27)28/h1-3,6-9,12-13,15,24-25,27H,4-5,10-11,14H2,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374739 (US10246467, Example I-10 | US10246467, Example I-1...) Show SMILES COc1cc2nn3[C@@H]4[C@H](COc3c2cc1C(O)=O)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O5/c1-42-24-11-21-17(10-18(24)29(39)40)28-38(36-21)27-23(13-43-28)37(12-14-5-6-14)31(25(27)16-3-2-4-20(33)26(16)34)19-8-7-15(32)9-22(19)35-30(31)41/h2-4,7-11,14,23,25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t23-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374789 (US10246467, Example I-109 | US10246467, Example I-...) Show SMILES Cc1c(ccc2nn3[C@@H]4[C@H](COc3c12)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12)C(O)=O |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c1-14-17(29(39)40)8-10-21-24(14)28-38(36-21)27-23(13-42-28)37(12-15-5-6-15)31(25(27)18-3-2-4-20(33)26(18)34)19-9-7-16(32)11-22(19)35-30(31)41/h2-4,7-11,15,23,25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t23-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374753 (US10246467, Example I-36 | US10246467, Example I-3...) Show SMILES CC(C)CN1[C@H]2COc3n(nc4cc(ccc34)C(O)=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C30H25Cl2FN4O4/c1-14(2)12-36-23-13-41-27-17-8-6-15(28(38)39)10-21(17)35-37(27)26(23)24(18-4-3-5-20(32)25(18)33)30(36)19-9-7-16(31)11-22(19)34-29(30)40/h3-11,14,23-24,26H,12-13H2,1-2H3,(H,34,40)(H,38,39)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374774 (US10246467, Example I-72 | US10919913, # I-72) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Br)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C30H23BrClFN4O4/c31-20-3-1-2-18(25(20)33)24-26-23(13-41-27-17-8-6-15(28(38)39)10-21(17)35-37(26)27)36(12-14-4-5-14)30(24)19-9-7-16(32)11-22(19)34-29(30)40/h1-3,6-11,14,23-24,26H,4-5,12-13H2,(H,34,40)(H,38,39)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374775 (US10246467, Example I-74 | US10919913, # I-74) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cc(Cl)cc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C30H22Cl3FN4O4/c31-15-4-6-19-22(10-15)35-29(41)30(19)24(18-8-16(32)9-20(33)25(18)34)26-23(37(30)11-13-1-2-13)12-42-27-17-5-3-14(28(39)40)7-21(17)36-38(26)27/h3-10,13,23-24,26H,1-2,11-12H2,(H,35,41)(H,39,40)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374787 (US10246467, Example I-105 | US10919913, # I-105) Show SMILES OC(=O)c1cc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2cc1F |r| Show InChI InChI=1S/C30H22Cl2F2N4O4/c31-14-6-7-18-22(8-14)35-29(41)30(18)24(15-2-1-3-19(32)25(15)34)26-23(37(30)11-13-4-5-13)12-42-27-17-9-16(28(39)40)20(33)10-21(17)36-38(26)27/h1-3,6-10,13,23-24,26H,4-5,11-12H2,(H,35,41)(H,39,40)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374786 (US10246467, Example I-92 | US10919913, # I-92) Show SMILES NC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5ccnc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C29H23Cl2FN6O3/c30-15-4-6-18-20(10-15)35-28(40)29(18)22(17-7-8-34-25(31)23(17)32)24-21(37(29)11-13-1-2-13)12-41-27-16-5-3-14(26(33)39)9-19(16)36-38(24)27/h3-10,13,21-22,24H,1-2,11-12H2,(H2,33,39)(H,35,40)/t21-,22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374776 (US10246467, Example I-76 | US10919913, # I-76) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5ccc(F)c(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C30H22Cl2F2N4O4/c31-15-4-7-18-21(10-15)35-29(41)30(18)23(17-6-8-19(33)24(32)25(17)34)26-22(37(30)11-13-1-2-13)12-42-27-16-5-3-14(28(39)40)9-20(16)36-38(26)27/h3-10,13,22-23,26H,1-2,11-12H2,(H,35,41)(H,39,40)/t22-,23-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374768 (US10246467, Example I-63 | US10919913, # I-63) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CCCOC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C32H27Cl2FN4O5/c33-18-7-9-21-24(12-18)36-31(42)32(21)26(20-4-1-5-22(34)27(20)35)28-25(38(32)13-16-3-2-10-43-14-16)15-44-29-19-8-6-17(30(40)41)11-23(19)37-39(28)29/h1,4-9,11-12,16,25-26,28H,2-3,10,13-15H2,(H,36,42)(H,40,41)/t16?,25-,26-,28+,32+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374792 (US10246467, Example I-112 | US10919913, # I-112) Show SMILES Cc1cc2nn3[C@@H]4[C@H](COc3c2cc1C(O)=O)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c1-14-9-22-19(11-18(14)29(39)40)28-38(36-22)27-24(13-42-28)37(12-15-5-6-15)31(25(27)17-3-2-4-21(33)26(17)34)20-8-7-16(32)10-23(20)35-30(31)41/h2-4,7-11,15,24-25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374753 (US10246467, Example I-36 | US10246467, Example I-3...) Show SMILES CC(C)CN1[C@H]2COc3n(nc4cc(ccc34)C(O)=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C30H25Cl2FN4O4/c1-14(2)12-36-23-13-41-27-17-8-6-15(28(38)39)10-21(17)35-37(27)26(23)24(18-4-3-5-20(32)25(18)33)30(36)19-9-7-16(31)11-22(19)34-29(30)40/h3-11,14,23-24,26H,12-13H2,1-2H3,(H,34,40)(H,38,39)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374788 (US10246467, Example I-107 | US10919913, # I-107) Show SMILES OC(=O)c1cc2nn3[C@@H]4[C@H](COc3c2cc1F)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C30H22Cl2F2N4O4/c31-14-6-7-18-22(8-14)35-29(41)30(18)24(15-2-1-3-19(32)25(15)34)26-23(37(30)11-13-4-5-13)12-42-27-17-9-20(33)16(28(39)40)10-21(17)36-38(26)27/h1-3,6-10,13,23-24,26H,4-5,11-12H2,(H,35,41)(H,39,40)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374739 (US10246467, Example I-10 | US10246467, Example I-1...) Show SMILES COc1cc2nn3[C@@H]4[C@H](COc3c2cc1C(O)=O)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O5/c1-42-24-11-21-17(10-18(24)29(39)40)28-38(36-21)27-23(13-43-28)37(12-14-5-6-14)31(25(27)16-3-2-4-20(33)26(16)34)19-8-7-15(32)9-22(19)35-30(31)41/h2-4,7-11,14,23,25,27H,5-6,12-13H2,1H3,(H,35,41)(H,39,40)/t23-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374750 (US10246467, Example I-32 | US10246467, Example I-3...) Show SMILES CC(C)(C)CN1[C@H]2COc3n(nc4cc(ccc34)C(O)=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H27Cl2FN4O4/c1-30(2,3)14-37-23-13-42-27-17-9-7-15(28(39)40)11-21(17)36-38(27)26(23)24(18-5-4-6-20(33)25(18)34)31(37)19-10-8-16(32)12-22(19)35-29(31)41/h4-12,23-24,26H,13-14H2,1-3H3,(H,35,41)(H,39,40)/t23-,24-,26+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374760 (US10246467, Example I-47 | US10919913, # I-47) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4(F)F)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C30H21Cl2F3N4O4/c31-15-5-7-18-21(9-15)36-28(42)30(18)23(17-2-1-3-19(32)24(17)33)25-22(38(30)11-14-10-29(14,34)35)12-43-26-16-6-4-13(27(40)41)8-20(16)37-39(25)26/h1-9,14,22-23,25H,10-12H2,(H,36,42)(H,40,41)/t14?,22-,23-,25+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374758 (US10246467, Example I-43 | US10919913, # I-43) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CCC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c32-17-8-10-20-23(12-17)35-30(41)31(20)25(19-5-2-6-21(33)26(19)34)27-24(37(31)13-15-3-1-4-15)14-42-28-18-9-7-16(29(39)40)11-22(18)36-38(27)28/h2,5-12,15,24-25,27H,1,3-4,13-14H2,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374784 (US10246467, Example I-90 | US10919913, # I-90) Show SMILES NC(=O)c1ccc2nn3[C@@H]4[C@H](COc3c2c1)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C30H24Cl2FN5O3/c31-16-7-8-19-22(11-16)35-29(40)30(19)24(17-2-1-3-20(32)25(17)33)26-23(37(30)12-14-4-5-14)13-41-28-18-10-15(27(34)39)6-9-21(18)36-38(26)28/h1-3,6-11,14,23-24,26H,4-5,12-13H2,(H2,34,39)(H,35,40)/t23-,24-,26+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374769 (US10246467, Example I-65 | US10919913, # I-65) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CCOCC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C32H27Cl2FN4O5/c33-18-5-7-21-24(13-18)36-31(42)32(21)26(20-2-1-3-22(34)27(20)35)28-25(38(32)14-16-8-10-43-11-9-16)15-44-29-19-6-4-17(30(40)41)12-23(19)37-39(28)29/h1-7,12-13,16,25-26,28H,8-11,14-15H2,(H,36,42)(H,40,41)/t25-,26-,28+,32+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374764 (US10246467, Example I-55 | US10919913, # I-55) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4C4CCCC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c32-16-9-11-20-23(13-16)35-30(41)31(20)25(19-6-3-7-21(33)26(19)34)27-24(37(31)17-4-1-2-5-17)14-42-28-18-10-8-15(29(39)40)12-22(18)36-38(27)28/h3,6-13,17,24-25,27H,1-2,4-5,14H2,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374767 (US10246467, Example I-61 | US10919913, # I-61) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4C4CCCCCC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C33H29Cl2FN4O4/c34-18-11-13-22-25(15-18)37-32(43)33(22)27(21-8-5-9-23(35)28(21)36)29-26(39(33)19-6-3-1-2-4-7-19)16-44-30-20-12-10-17(31(41)42)14-24(20)38-40(29)30/h5,8-15,19,26-27,29H,1-4,6-7,16H2,(H,37,43)(H,41,42)/t26-,27-,29+,33+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374780 (US10246467, Example I-84 | US10919913, # I-84) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4nc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C29H22Cl2FN5O4/c30-18-3-1-2-16(23(18)32)22-24-20(12-41-26-15-7-6-14(27(38)39)10-19(15)35-37(24)26)36(11-13-4-5-13)29(22)17-8-9-21(31)33-25(17)34-28(29)40/h1-3,6-10,13,20,22,24H,4-5,11-12H2,(H,38,39)(H,33,34,40)/t20-,22-,24+,29+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374781 (US10246467, Example I-86 | US10919913, # I-86) Show SMILES OC(=O)c1ccc2c3OCC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c32-17-7-9-20-23(13-17)35-30(41)31(20)25(19-2-1-3-21(33)26(19)34)27-24(37(31)14-15-4-5-15)10-11-42-28-18-8-6-16(29(39)40)12-22(18)36-38(27)28/h1-3,6-9,12-13,15,24-25,27H,4-5,10-11,14H2,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374766 (US10246467, Example I-59 | US10919913, # I-59) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4C4CCCCC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C32H27Cl2FN4O4/c33-17-10-12-21-24(14-17)36-31(42)32(21)26(20-7-4-8-22(34)27(20)35)28-25(38(32)18-5-2-1-3-6-18)15-43-29-19-11-9-16(30(40)41)13-23(19)37-39(28)29/h4,7-14,18,25-26,28H,1-3,5-6,15H2,(H,36,42)(H,40,41)/t25-,26-,28+,32+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374761 (US10246467, Example I-49 | US10919913, # I-49) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CCCC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C32H27Cl2FN4O4/c33-18-9-11-21-24(13-18)36-31(42)32(21)26(20-6-3-7-22(34)27(20)35)28-25(38(32)14-16-4-1-2-5-16)15-43-29-19-10-8-17(30(40)41)12-23(19)37-39(28)29/h3,6-13,16,25-26,28H,1-2,4-5,14-15H2,(H,36,42)(H,40,41)/t25-,26-,28+,32+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374782 (US10246467, Example I-87 | US10919913, # I-87) Show SMILES COc1cc2c3OCC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2cc1C(O)=O |r| Show InChI InChI=1S/C32H27Cl2FN4O5/c1-43-25-13-18-22(12-19(25)30(40)41)37-39-28-24(9-10-44-29(18)39)38(14-15-5-6-15)32(26(28)17-3-2-4-21(34)27(17)35)20-8-7-16(33)11-23(20)36-31(32)42/h2-4,7-8,11-13,15,24,26,28H,5-6,9-10,14H2,1H3,(H,36,42)(H,40,41)/t24-,26-,28+,32+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374757 (US10246467, Example I-41 | US10919913, # I-41) Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#7]1-[#6@H]-2-[#6]-[#8]-c3n(nc4cc(ccc34)-[#6](-[#8])=O)-[#6@H]-2-[#6@H](-c2cccc(Cl)c2F)[C@]11[#6](=O)-[#7]-c2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c1-15(2)10-11-37-24-14-42-28-18-8-6-16(29(39)40)12-22(18)36-38(28)27(24)25(19-4-3-5-21(33)26(19)34)31(37)20-9-7-17(32)13-23(20)35-30(31)41/h3-10,12-13,24-25,27H,11,14H2,1-2H3,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374762 (US10246467, Example I-51 | US10919913, # I-51) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CCOC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C31H25Cl2FN4O5/c32-17-5-7-20-23(11-17)35-30(41)31(20)25(19-2-1-3-21(33)26(19)34)27-24(37(31)12-15-8-9-42-13-15)14-43-28-18-6-4-16(29(39)40)10-22(18)36-38(27)28/h1-7,10-11,15,24-25,27H,8-9,12-14H2,(H,35,41)(H,39,40)/t15?,24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374756 (US10246467, Example I-39 | US10919913, # I-39) Show SMILES CC(C)CCN1[C@H]2COc3n(nc4cc(ccc34)C(O)=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H27Cl2FN4O4/c1-15(2)10-11-37-24-14-42-28-18-8-6-16(29(39)40)12-22(18)36-38(28)27(24)25(19-4-3-5-21(33)26(19)34)31(37)20-9-7-17(32)13-23(20)35-30(31)41/h3-9,12-13,15,24-25,27H,10-11,14H2,1-2H3,(H,35,41)(H,39,40)/t24-,25-,27+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374763 (US10246467, Example I-53 | US10919913, # I-53) Show SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CCCCC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C33H29Cl2FN4O4/c34-19-10-12-22-25(14-19)37-32(43)33(22)27(21-7-4-8-23(35)28(21)36)29-26(39(33)15-17-5-2-1-3-6-17)16-44-30-20-11-9-18(31(41)42)13-24(20)38-40(29)30/h4,7-14,17,26-27,29H,1-3,5-6,15-16H2,(H,37,43)(H,41,42)/t26-,27-,29+,33+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374742 (US10246467, Example I-13 | US10246467, Example I-1...) Show SMILES CS(=O)(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1 |r| Show InChI InChI=1S/C30H25Cl2FN4O4S/c1-42(39,40)17-8-9-18-22(12-17)35-37-27-24(14-41-28(18)37)36(13-15-5-6-15)30(25(27)19-3-2-4-21(32)26(19)33)20-10-7-16(31)11-23(20)34-29(30)38/h2-4,7-12,15,24-25,27H,5-6,13-14H2,1H3,(H,34,38)/t24-,25-,27+,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117] (Homo sapiens (Human))	BDBM374746 (US10246467, Example I-28 | US10919913, # I-28) Show SMILES C[C@H]1Oc2n(nc3cc(ccc23)C(O)=O)[C@@H]2[C@H]1N(CC1CC1)[C@]1([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r| Show InChI InChI=1S/C31H25Cl2FN4O4/c1-14-26-27(38-28(42-14)18-9-7-16(29(39)40)11-22(18)36-38)24(19-3-2-4-21(33)25(19)34)31(37(26)13-15-5-6-15)20-10-8-17(32)12-23(20)35-30(31)41/h2-4,7-12,14-15,24,26-27H,5-6,13H2,1H3,(H,35,41)(H,39,40)/t14-,24+,26+,27+,31-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2VX0JT2
					More data for this Ligand-Target Pair

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