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Compile Data Set for Download or QSAR

Found 151 hits of ic50 for UniProtKB: P36888   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476704
PNG
( (3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-di...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(CO)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-13-36(14-18(2)33-17)15-20-7-22(21-4-5-21)10-23(8-20)34-29-32-12-26(30)28(35-29)25-11-31-27-9-19(16-37)3-6-24(25)27/h3,6-12,17-18,21,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t17-,18+
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n/an/a 0.5n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM546731
PNG
((3-(5-chloro-2-((3-cyclopropyl-5-(((3R, 5S)-3,5-di...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3cn(c4cc(CO)ccc34)S(=O)(=O)c3ccc(C)cc3)cc(c2)C2CC2)C[C@@H](C)N1 |r|
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50377170
PNG
(CHEMBL256570 | US11254667, Compound I-2 | US115422...)
Show SMILES Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1
Show InChI InChI=1S/C17H18ClN5/c18-12-4-5-17-20-10-15(23(17)11-12)14-2-1-3-16(22-14)21-13-6-8-19-9-7-13/h1-5,10-11,13,19H,6-9H2,(H,21,22)
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n/an/a<0.5n/an/an/an/an/an/a


TBA

Assay Description
Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538621
PNG
(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Show SMILES Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1
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n/an/a<0.508n/an/an/an/an/an/a


TBA

Assay Description
Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538619
PNG
(NCGC 00371479 | US11254667, Compound I-22 | US1154...)
Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cccnc1
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n/an/a<0.508n/an/an/an/an/an/a


TBA

Assay Description
Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538618
PNG
(NCGC 00262327 | US11254667, Compound I-20 | US1154...)
Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cn[nH]c1
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n/an/a<0.508n/an/an/an/an/an/a


TBA

Assay Description
Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538658
PNG
(NCGC 00249373 | US11254667, Compound I-17 | US1154...)
Show SMILES Clc1ccc2ncc(-c3cccc(NC4CCCNC4)n3)n2c1
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n/an/a<0.508n/an/an/an/an/an/a


TBA

Assay Description
Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538619
PNG
(NCGC 00371479 | US11254667, Compound I-22 | US1154...)
Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cccnc1
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n/an/a<0.508n/an/an/an/an/an/a


TBA

Assay Description
Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM139540
PNG
(US10189849, staurosporine | US10307427, Staurospor...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1
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TBA

Assay Description
Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538621
PNG
(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Show SMILES Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1
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n/an/a<0.508n/an/an/an/an/an/a


TBA

Assay Description
Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622513
PNG
(US20230312583, Compound I-9)
Show SMILES CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2CC(C1)N2
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n/an/a 0.880n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622506
PNG
(US20230312583, Compound I-2)
Show SMILES CCN1CCN(CC1)c1cnc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)cc1OC
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n/an/a 1.09n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622516
PNG
(US20230312583, Compound I-12)
Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2CCC1CN2
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n/an/a 1.26n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622511
PNG
(US20230312583, Compound I-7)
Show SMILES CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCN(C)CC1
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n/an/a 1.34n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622523
PNG
(US20230312583, Compound V-1)
Show SMILES CCOc1cc(Nc2ncc3ccc4ncn(CC)c4c3n2)ncc1N1CCN(CC)CC1
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n/an/a 1.44n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622524
PNG
(US20230312583, Compound VI-1)
Show SMILES COc1cc(Nc2ncc3ccc4nc(C)n(C(C)C)c4c3n2)ncc1N1CCOCC1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476695
PNG
(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(Cl)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C28H30Cl2N6/c1-16-13-36(14-17(2)33-16)15-18-7-20(19-3-4-19)9-22(8-18)34-28-32-12-25(30)27(35-28)24-11-31-26-10-21(29)5-6-23(24)26/h5-12,16-17,19,31,33H,3-4,13-15H2,1-2H3,(H,32,34,35)/t16-,17+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476695
PNG
(5-chloro-4-(6-chloro-1H-indole-3-yl)-N-(3-cyclopro...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(Cl)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C28H30Cl2N6/c1-16-13-36(14-17(2)33-16)15-18-7-20(19-3-4-19)9-22(8-18)34-28-32-12-25(30)27(35-28)24-11-31-26-10-21(29)5-6-23(24)26/h5-12,16-17,19,31,33H,3-4,13-15H2,1-2H3,(H,32,34,35)/t16-,17+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM139540
PNG
(US10189849, staurosporine | US10307427, Staurospor...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1
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n/an/a 1.56n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622515
PNG
(US20230312583, Compound I-11)
Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1C2CCC1CNC2
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n/an/a 1.58n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622505
PNG
(US20230312583, Compound I-1)
Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCN(C)CC1
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n/an/a 1.59n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476700
PNG
(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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n/an/a 1.80n/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476699
PNG
((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)CCN1
Show InChI InChI=1S/C27H29ClN6/c1-17-15-34(9-8-29-17)16-18-10-20(19-6-7-19)12-21(11-18)32-27-31-14-24(28)26(33-27)23-13-30-25-5-3-2-4-22(23)25/h2-5,10-14,17,19,29-30H,6-9,15-16H2,1H3,(H,31,32,33)/t17-/m1/s1
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476700
PNG
(5-chloro-N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethyl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476699
PNG
((R)-5-chloro-N-(3-cyclopropyl-5-((3-methylpiperazi...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)CCN1
Show InChI InChI=1S/C27H29ClN6/c1-17-15-34(9-8-29-17)16-18-10-20(19-6-7-19)12-21(11-18)32-27-31-14-24(28)26(33-27)23-13-30-25-5-3-2-4-22(23)25/h2-5,10-14,17,19,29-30H,6-9,15-16H2,1H3,(H,31,32,33)/t17-/m1/s1
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Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50300690
PNG
(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
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Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622509
PNG
(US20230312583, Compound I-5)
Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCNC(C)(C)C1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622508
PNG
(US20230312583, Compound I-4)
Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2(CNC2)C1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476711
PNG
( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@H](CO)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-3-6-24-25(11-31-27(24)7-17)28-26(30)12-32-29(35-28)34-22-9-19(8-21(10-22)20-4-5-20)14-36-13-18(2)33-23(15-36)16-37/h3,6-12,18,20,23,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t18-,23-/m1/s1
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476711
PNG
( ((2R,6R)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-...)
Show SMILES C[C@@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@H](CO)N1
Show InChI InChI=1S/C29H33ClN6O/c1-17-3-6-24-25(11-31-27(24)7-17)28-26(30)12-32-29(35-28)34-22-9-19(8-21(10-22)20-4-5-20)14-36-13-18(2)33-23(15-36)16-37/h3,6-12,18,20,23,31,33,37H,4-5,13-16H2,1-2H3,(H,32,34,35)/t18-,23-/m1/s1
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The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476708
PNG
(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4c(O)c(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-16-4-7-23-24(11-31-27(23)28(16)37)26-25(30)12-32-29(35-26)34-22-9-19(8-21(10-22)20-5-6-20)15-36-13-17(2)33-18(3)14-36/h4,7-12,17-18,20,31,33,37H,5-6,13-15H2,1-3H3,(H,32,34,35)/t17-,18+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476708
PNG
(3-(5-chloro-2-((3-cyclopropyl-5-(((3R,5S)-3,5-dime...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4c(O)c(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33ClN6O/c1-16-4-7-23-24(11-31-27(23)28(16)37)26-25(30)12-32-29(35-26)34-22-9-19(8-21(10-22)20-5-6-20)15-36-13-17(2)33-18(3)14-36/h4,7-12,17-18,20,31,33,37H,5-6,13-15H2,1-3H3,(H,32,34,35)/t17-,18+
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Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476702
PNG
(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(F)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33FN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476702
PNG
(N-(3-cyclopropyl-5-(((3R,5S)-3,5-dimethylpiperazin...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(F)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1
Show InChI InChI=1S/C29H33FN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622520
PNG
(US20230312583, Compound II-1)
Show SMILES COc1cc(Nc2ncc3cc(C)c4ncn(C(C)C)c4c3n2)ccc1N1CCOCC1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622512
PNG
(US20230312583, Compound I-8)
Show SMILES CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCOCC1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622517
PNG
(US20230312583, Compound I-13)
Show SMILES CC#CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCNCC1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476697
PNG
(2-((2R,6S)-4-(3-((5-chloro-4-(1H-indole-3-yl)pyrim...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)C[C@@H](C)N1CCO
Show InChI InChI=1S/C30H35ClN6O/c1-19-16-36(17-20(2)37(19)9-10-38)18-21-11-23(22-7-8-22)13-24(12-21)34-30-33-15-27(31)29(35-30)26-14-32-28-6-4-3-5-25(26)28/h3-6,11-15,19-20,22,32,38H,7-10,16-18H2,1-2H3,(H,33,34,35)/t19-,20+
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476697
PNG
(2-((2R,6S)-4-(3-((5-chloro-4-(1H-indole-3-yl)pyrim...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)cc(c2)C2CC2)C[C@@H](C)N1CCO
Show InChI InChI=1S/C30H35ClN6O/c1-19-16-36(17-20(2)37(19)9-10-38)18-21-11-23(22-7-8-22)13-24(12-21)34-30-33-15-27(31)29(35-30)26-14-32-28-6-4-3-5-25(26)28/h3-6,11-15,19-20,22,32,38H,7-10,16-18H2,1-2H3,(H,33,34,35)/t19-,20+
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476701
PNG
(US10870639, Example 10 | US11292786, Example 10 | ...)
Show SMILES CC1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)CC(C)N1
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HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476701
PNG
(US10870639, Example 10 | US11292786, Example 10 | ...)
Show SMILES CC1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)CC(C)N1
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TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622514
PNG
(US20230312583, Compound I-10)
Show SMILES CC(C)n1cnc2ccc3cnc(Nc4cc(OCC5CC5)c(cn4)N4CCNCC4)nc3c12
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM622507
PNG
(US20230312583, Compound I-3)
Show SMILES COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2(COC2)C1
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TBA



Citation and Details
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538621
PNG
(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Show SMILES Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1
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TBA

Assay Description
Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50300690
PNG
(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
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TBA

Assay Description
Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538618
PNG
(NCGC 00262327 | US11254667, Compound I-20 | US1154...)
Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cn[nH]c1
PDB
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n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM538621
PNG
(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Show SMILES Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1
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n/an/a<5n/an/an/an/an/an/a


TBA

Assay Description
Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM588615
PNG
(NCGC00262326 | US11542261, Compound I-21)
Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1Cl
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n/an/a 6n/an/an/an/an/an/a


TBA

Assay Description
Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2154MW8
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476712
PNG
((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1O
Show InChI InChI=1S/C29H33ClN6O/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(34-28)33-23-10-20(9-22(11-23)21-5-6-21)16-35-14-18(2)36(37)19(3)15-35/h4,7-13,18-19,21,31,37H,5-6,14-16H2,1-3H3,(H,32,33,34)/t18-,19+
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n/an/a 6.90n/an/an/an/an/an/a


TBA

Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured. Th...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2VX0KQ4
More data for this
Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM476712
PNG
((2R,6S)-4-(3-((5-chloro-4-(6-methyl-1H-indole-3-yl...)
Show SMILES C[C@H]1CN(Cc2cc(Nc3ncc(Cl)c(n3)-c3c[nH]c4cc(C)ccc34)cc(c2)C2CC2)C[C@@H](C)N1O
Show InChI InChI=1S/C29H33ClN6O/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(34-28)33-23-10-20(9-22(11-23)21-5-6-21)16-35-14-18(2)36(37)19(3)15-35/h4,7-13,18-19,21,31,37H,5-6,14-16H2,1-3H3,(H,32,33,34)/t18-,19+
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n/an/a 6.90n/an/an/an/an/an/a



HANMI PHARM. CO.. LTD.

US Patent


Assay Description
The inhibitory activity of some of the compounds described above against FLT3-ITD, FLT3 wild type (WT), VEGFR2 (KDR), and SYK kinase was measured.The...

US Patent US10870639 (2020)


BindingDB Entry DOI: 10.7270/Q20G3P70
More data for this
Ligand-Target Pair
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