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Compile Data Set for Download or QSAR

Found 46 hits of ic50 for UniProtKB: P11362   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168394
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-isopropyl-[1,3,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H23F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11(3)4)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-5)14(23)7-15(16)24/h6-11H,1-5H3,(H,30,32)(H,25,26,27)
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n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50322535
PNG
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
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n/an/a 2.20n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c02167
BindingDB Entry DOI: 10.7270/Q22R3WQ4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168397
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-oxazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4ncc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H20F2N6O3/c1-10(2)17-13(21-24-7-11(3)32-21)8-29-18(17)19(25-9-26-29)27-16-5-12(20(30)28-31-4)14(22)6-15(16)23/h5-10H,1-4H3,(H,28,30)(H,25,26,27)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168398
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methanesulfonylme...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CS(C)(=O)=O)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H21F2N7O5S/c1-10(2)17-12(21-28-27-16(35-21)8-36(4,32)33)7-30-18(17)19(24-9-25-30)26-15-5-11(20(31)29-34-3)13(22)6-14(15)23/h5-7,9-10H,8H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 4.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168410
PNG
(5-[6-(5-Ethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-p...)
Show SMILES CCc1nnc(o1)-c1cn2ncnc(Nc3cc(C(=O)NOC)c(F)cc3F)c2c1C(C)C
Show InChI InChI=1S/C21H21F2N7O3/c1-5-16-27-28-21(33-16)12-8-30-18(17(12)10(2)3)19(24-9-25-30)26-15-6-11(20(31)29-32-4)13(22)7-14(15)23/h6-10H,5H2,1-4H3,(H,29,31)(H,24,25,26)
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n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168391
PNG
(5-[6-(5-Cyclopropyl-[1,3,4]oxadiazol-2-yl)-5-isopr...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C4CC4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C22H21F2N7O3/c1-10(2)17-13(22-29-28-21(34-22)11-4-5-11)8-31-18(17)19(25-9-26-31)27-16-6-12(20(32)30-33-3)14(23)7-15(16)24/h6-11H,4-5H2,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 5.30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168387
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-27-26-10(3)32-20)7-29-17(16)18(23-8-24-29)25-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,25)
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n/an/a 6.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168390
PNG
(2,4-Difluoro-5-[6-(5-isobutyl-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(C)C)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H25F2N7O3/c1-11(2)6-18-29-30-23(35-18)14-9-32-20(19(14)12(3)4)21(26-10-27-32)28-17-7-13(22(33)31-34-5)15(24)8-16(17)25/h7-12H,6H2,1-5H3,(H,31,33)(H,26,27,28)
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n/an/a 6.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168393
PNG
(5-[6-(5-Dimethylamino-[1,3,4]oxadiazol-2-yl)-5-iso...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)N(C)C)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H22F2N8O3/c1-10(2)16-12(20-27-28-21(34-20)30(3)4)8-31-17(16)18(24-9-25-31)26-15-6-11(19(32)29-33-5)13(22)7-14(15)23/h6-10H,1-5H3,(H,29,32)(H,24,25,26)
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n/an/a 7.30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168400
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(3-methyl-[1,2,4]oxa...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nc(C)no4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H19F2N7O3/c1-9(2)16-12(20-25-10(3)27-32-20)7-29-17(16)18(23-8-24-29)26-15-5-11(19(30)28-31-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,28,30)(H,23,24,26)
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n/an/a 7.60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168388
PNG
(5-[6-(5-Cyclopropylmethyl-[1,3,4]oxadiazol-2-yl)-5...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC5CC5)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C23H23F2N7O3/c1-11(2)19-14(23-30-29-18(35-23)6-12-4-5-12)9-32-20(19)21(26-10-27-32)28-17-7-13(22(33)31-34-3)15(24)8-16(17)25/h7-12H,4-6H2,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 9.20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168403
PNG
(5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-is...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H17F4N7O3/c1-8(2)14-10(19-28-29-20(34-19)16(23)24)6-31-15(14)17(25-7-26-31)27-13-4-9(18(32)30-33-3)11(21)5-12(13)22/h4-8,16H,1-3H3,(H,30,32)(H,25,26,27)
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n/an/a 21n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50566726
PNG
(CHEMBL4868909)
Show SMILES COc1cccc(c1)-c1cc(nc(N)c1C#N)-c1c(O)c2ccccc2oc1=O
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n/an/a 21n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FGFR (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 27n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FGFR (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168407
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-trifluoromethyl-[...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)F)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H16F5N7O3/c1-8(2)14-10(18-29-30-19(35-18)20(23,24)25)6-32-15(14)16(26-7-27-32)28-13-4-9(17(33)31-34-3)11(21)5-12(13)22/h4-8H,1-3H3,(H,31,33)(H,26,27,28)
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n/an/a 33n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168395
PNG
(2,4-Difluoro-5-{5-isopropyl-6-[5-(2,2,2-trifluoro-...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(CC(F)(F)F)o4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H18F5N7O3/c1-9(2)16-11(20-31-30-15(36-20)6-21(24,25)26)7-33-17(16)18(27-8-28-33)29-14-4-10(19(34)32-35-3)12(22)5-13(14)23/h4-5,7-9H,6H2,1-3H3,(H,32,34)(H,27,28,29)
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n/an/a 44n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168406
PNG
(2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-4H-[1,2,4]...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)[nH]4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C20H20F2N8O2/c1-9(2)16-12(18-25-10(3)27-28-18)7-30-17(16)19(23-8-24-30)26-15-5-11(20(31)29-32-4)13(21)6-14(15)22/h5-9H,1-4H3,(H,29,31)(H,23,24,26)(H,25,27,28)
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n/an/a 46n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168404
PNG
(2,4-Difluoro-5-(5-isopropyl-6-[1,3,4]oxadiazol-2-y...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnco4)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C19H17F2N7O3/c1-9(2)15-11(19-26-23-8-31-19)6-28-16(15)17(22-7-24-28)25-14-4-10(18(29)27-30-3)12(20)5-13(14)21/h4-9H,1-3H3,(H,27,29)(H,22,24,25)
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n/an/a 54n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50182212
PNG
(7-(4-fluorophenylamino)-1-((1S,3R)-3-hydroxycyclop...)
Show SMILES COc1ccc(cc1)N1Cc2cnc(Nc3ccc(F)cc3)nc2N(C2CC[C@@H](O)C2)C1=O
Show InChI InChI=1S/C24H24FN5O3/c1-33-21-10-7-18(8-11-21)29-14-15-13-26-23(27-17-4-2-16(25)3-5-17)28-22(15)30(24(29)32)19-6-9-20(31)12-19/h2-5,7-8,10-11,13,19-20,31H,6,9,12,14H2,1H3,(H,26,27,28)/t19?,20-/m1/s1
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n/an/a 92n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human FGFR


Bioorg Med Chem Lett 16: 1950-3 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.092
BindingDB Entry DOI: 10.7270/Q2S46SRS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50168402
PNG
(5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]o...)
Show SMILES CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(o4)C(F)(F)S(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
Show InChI InChI=1S/C21H19F4N7O5S/c1-9(2)15-11(19-29-30-20(37-19)21(24,25)38(4,34)35)7-32-16(15)17(26-8-27-32)28-14-5-10(18(33)31-36-3)12(22)6-13(14)23/h5-9H,1-4H3,(H,31,33)(H,26,27,28)
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n/an/a 130n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 48: 3991-4008 (2005)


Article DOI: 10.1021/jm0501275
BindingDB Entry DOI: 10.7270/Q2KP81QN
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM13535
PNG
(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Show InChI InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
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n/an/a 170n/an/an/an/an/an/a



Vichem Chemie Research Ltd

Curated by ChEMBL


Assay Description
Inhibition of FGFR (unknown origin)


Eur J Med Chem 184: (2019)


Article DOI: 10.1016/j.ejmech.2019.111710
BindingDB Entry DOI: 10.7270/Q27947ZV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor


J Med Chem 45: 3772-93 (2002)


BindingDB Entry DOI: 10.7270/Q2WW7JD9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50512149
PNG
(CHEMBL4470529)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCN(CCN(C)C)C1=O
Show InChI InChI=1S/C27H34ClN7O4S/c1-18(2)40(37,38)24-9-7-6-8-22(24)30-25-20(28)17-29-26(32-25)31-21-11-10-19(16-23(21)39-5)35-15-14-34(27(35)36)13-12-33(3)4/h6-11,16-18H,12-15H2,1-5H3,(H2,29,30,31,32)
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n/an/a 573n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of FGFR (unknown origin) incubated for 1 hr by mobility shift assay


Eur J Med Chem 171: 297-309 (2019)


Article DOI: 10.1016/j.ejmech.2019.03.038
BindingDB Entry DOI: 10.7270/Q28G8Q13
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM26198
PNG
(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)
Show SMILES CC(C)(C)c1nc2c([nH]1)c1ccc(F)cc1c1c2cc[nH]c1=O
Show InChI InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
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n/an/a 1.48E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor


Bioorg Med Chem Lett 12: 1219-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JW8D67
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50214802
PNG
(CHEMBL316508)
Show SMILES NC(=O)C1=C2CCCc3cccc(C1=O)c23 |c:3|
Show InChI InChI=1S/C13H11NO2/c14-13(16)11-8-5-1-3-7-4-2-6-9(10(7)8)12(11)15/h2,4,6H,1,3,5H2,(H2,14,16)
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n/an/a 4.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50290825
PNG
(1-Oxo-3-phenyl-1H-indene-2-carboxylic acid amide |...)
Show SMILES NC(=O)C1=C(c2ccccc2C1=O)c1ccccc1 |t:3|
Show InChI InChI=1S/C16H11NO2/c17-16(19)14-13(10-6-2-1-3-7-10)11-8-4-5-9-12(11)15(14)18/h1-9H,(H2,17,19)
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n/an/a 4.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50290820
PNG
(1-Oxo-3-phenyl-1H-indene-2-carboxylic acid methyl ...)
Show SMILES COC(=O)C1=C(c2ccccc2C1=O)c1ccccc1 |t:4|
Show InChI InChI=1S/C17H12O3/c1-20-17(19)15-14(11-7-3-2-4-8-11)12-9-5-6-10-13(12)16(15)18/h2-10H,1H3
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n/an/a 5.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50290831
PNG
(3-(4-Chloro-phenyl)-1-oxo-1H-indene-2-carboxylic a...)
Show SMILES NC(=O)C1=C(c2ccccc2C1=O)c1ccc(Cl)cc1 |t:3|
Show InChI InChI=1S/C16H10ClNO2/c17-10-7-5-9(6-8-10)13-11-3-1-2-4-12(11)15(19)14(13)16(18)20/h1-8H,(H2,18,20)
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n/an/a 5.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50214800
PNG
(CHEMBL316556)
Show SMILES COC(=O)C1=C(c2cc(Cl)ccc2C1=O)c1ccccc1.COC(=O)C1=C(c2ccc(Cl)cc2C1=O)c1ccccc1 |t:4,27|
Show InChI InChI=1S/C17H11ClO3/c1-21-17(20)15-14(10-5-3-2-4-6-10)12-8-7-11(18)9-13(12)16(15)19/h2-9H,1H3
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n/an/a 6.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50290822
PNG
(5-Methyl-1-oxo-3-phenyl-1H-indene-2-carboxylic aci...)
Show SMILES COC(=O)C1=C(c2ccc(C)cc2C1=O)c1ccccc1 |t:4|
Show InChI InChI=1S/C18H14O3/c1-11-8-9-13-14(10-11)17(19)16(18(20)21-2)15(13)12-6-4-3-5-7-12/h3-10H,1-2H3
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n/an/a 6.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50290823
PNG
(7-Oxo-5-phenyl-7H-[2]pyrindine-6-carboxylic acid m...)
Show SMILES COC(=O)C1=C(c2ccncc2C1=O)c1ccccc1 |t:4|
Show InChI InChI=1S/C16H11NO3/c1-20-16(19)14-13(10-5-3-2-4-6-10)11-7-8-17-9-12(11)15(14)18/h2-9H,1H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50181532
PNG
(CHEMBL201307 | N-(3-fluorophenyl)-2-(2-(7-(3-(4-(h...)
Show SMILES COc1cc2c(Nc3ncc(CC(=O)Nc4cccc(F)c4)s3)ncnc2cc1OCCCN1CCC(CO)CC1
Show InChI InChI=1S/C29H33FN6O4S/c1-39-25-14-23-24(15-26(25)40-11-3-8-36-9-6-19(17-37)7-10-36)32-18-33-28(23)35-29-31-16-22(41-29)13-27(38)34-21-5-2-4-20(30)12-21/h2,4-5,12,14-16,18-19,37H,3,6-11,13,17H2,1H3,(H,34,38)(H,31,32,33,35)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against FGFR


J Med Chem 49: 955-70 (2006)


Article DOI: 10.1021/jm050786h
BindingDB Entry DOI: 10.7270/Q24J0FXV
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50214804
PNG
(CHEMBL99077)
Show SMILES CCC1=C(C(N)=O)C(=O)c2ccccc12 |c:2|
Show InChI InChI=1S/C12H11NO2/c1-2-7-8-5-3-4-6-9(8)11(14)10(7)12(13)15/h3-6H,2H2,1H3,(H2,13,15)
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n/an/a 9.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50499634
PNG
(CHEMBL3741589)
Show SMILES OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1
Show InChI InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AbbVie Bioresearch Center

Curated by ChEMBL


Assay Description
Inhibition of FGFR (unknown origin)


J Med Chem 58: 9154-70 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00928
BindingDB Entry DOI: 10.7270/Q2PZ5CV4
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50290824
PNG
(6-Nitro-1-oxo-3-phenyl-1H-indene-2-carboxylic acid...)
Show SMILES COC(=O)C1=C(c2ccc(cc2C1=O)[N+]([O-])=O)c1ccccc1 |t:4|
Show InChI InChI=1S/C17H11NO5/c1-23-17(20)15-14(10-5-3-2-4-6-10)12-8-7-11(18(21)22)9-13(12)16(15)19/h2-9H,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50290821
PNG
(3-(4-Methoxy-phenyl)-1-oxo-1H-indene-2-carboxylic ...)
Show SMILES COc1ccc(cc1)C1=C(C(N)=O)C(=O)c2ccccc12 |c:9|
Show InChI InChI=1S/C17H13NO3/c1-21-11-8-6-10(7-9-11)14-12-4-2-3-5-13(12)16(19)15(14)17(18)20/h2-9H,1H3,(H2,18,20)
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n/an/a 1.06E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM21079
PNG
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
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n/an/a 1.25E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR


J Med Chem 50: 1584-97 (2007)


Article DOI: 10.1021/jm061280h
BindingDB Entry DOI: 10.7270/Q2DJ5F95
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50290827
PNG
(4-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic ac...)
Show SMILES COC(=O)C1=C(c2c(cccc2OC)C1=O)c1ccccc1 |t:4|
Show InChI InChI=1S/C18H14O4/c1-21-13-10-6-9-12-15(13)14(11-7-4-3-5-8-11)16(17(12)19)18(20)22-2/h3-10H,1-2H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50214801
PNG
(CHEMBL99352)
Show SMILES CNC(=O)C1=C(c2ccccc2C1=O)c1ccccc1 |t:4|
Show InChI InChI=1S/C17H13NO2/c1-18-17(20)15-14(11-7-3-2-4-8-11)12-9-5-6-10-13(12)16(15)19/h2-10H,1H3,(H,18,20)
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n/an/a 2.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FGF receptor


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50214799
PNG
(CHEMBL98396)
Show SMILES OC(=O)C1=C(c2ccccc2C1=O)c1ccccc1 |t:3|
Show InChI InChI=1S/C16H10O3/c17-15-12-9-5-4-8-11(12)13(14(15)16(18)19)10-6-2-1-3-7-10/h1-9H,(H,18,19)
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n/an/a 2.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50117319
PNG
(4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazol...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCOCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Show InChI InChI=1S/C30H40N6O5/c1-22(2)41-24-7-5-23(6-8-24)33-30(37)36-12-10-35(11-13-36)29-25-19-27(38-3)28(20-26(25)31-21-32-29)40-16-4-9-34-14-17-39-18-15-34/h5-8,19-22H,4,9-18H2,1-3H3,(H,33,37)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor


J Med Chem 45: 3772-93 (2002)


BindingDB Entry DOI: 10.7270/Q2WW7JD9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM13535
PNG
(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
Show InChI InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor


J Med Chem 45: 3772-93 (2002)


BindingDB Entry DOI: 10.7270/Q2WW7JD9
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50188272
PNG
(7-((1H-imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4...)
Show SMILES C(c1ccc2Cc3c(n[nH]c3-c3ccsc3)-c2c1)n1ccnc1
Show InChI InChI=1S/C18H14N4S/c1-2-13-8-16-17(14-3-6-23-10-14)20-21-18(16)15(13)7-12(1)9-22-5-4-19-11-22/h1-7,10-11H,8-9H2,(H,20,21)
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n/an/a 3.44E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50214803
PNG
(CHEMBL99049)
Show SMILES COC(=O)C1=C(c2cccc(C)c2C1=O)c1ccccc1 |t:4|
Show InChI InChI=1S/C18H14O3/c1-11-7-6-10-13-14(11)17(19)16(18(20)21-2)15(13)12-8-4-3-5-9-12/h3-10H,1-2H3
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n/an/a 4.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against fibroblast growth factor receptor (FGFr)


Bioorg Med Chem Lett 7: 2903-2908 (1997)


Article DOI: 10.1016/S0960-894X(97)10110-X
BindingDB Entry DOI: 10.7270/Q24Q7V03
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50188266
PNG
(7-((4-methylpiperazin-1-yl)methyl)-3-(thiophen-3-y...)
Show SMILES CN1CCN(Cc2ccc3Cc4c(n[nH]c4-c4ccsc4)-c3c2)CC1
Show InChI InChI=1S/C20H22N4S/c1-23-5-7-24(8-6-23)12-14-2-3-15-11-18-19(16-4-9-25-13-16)21-22-20(18)17(15)10-14/h2-4,9-10,13H,5-8,11-12H2,1H3,(H,21,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR by HTRF assay


Bioorg Med Chem Lett 16: 4371-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.052
BindingDB Entry DOI: 10.7270/Q2QJ7GX6
More data for this
Ligand-Target Pair