Found 42 hits of ec50 for UniProtKB: P34975 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM60212
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1 | PDB
UniProtKB/SwissProt
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DrugBank MCE KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to rat brain opioid receptor |
J Med Chem 21: 101-6 (1978)
Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496883
(CHEMBL3228684)Show SMILES OS(O)(=O)=O.[H][C@@]12CCC[C@@]3([H])[C@@]4([H])Cc5ccc(O)c(O1)c5[C@@]23CCN4C |r,TLB:27:26:10:22.15.14| Show InChI InChI=1S/C17H21NO2.H2O4S/c1-18-8-7-17-11-3-2-4-14(17)20-16-13(19)6-5-10(15(16)17)9-12(11)18;1-5(2,3)4/h5-6,11-12,14,19H,2-4,7-9H2,1H3;(H2,1,2,3,4)/t11-,12+,14-,17+;/m0./s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM82427
(CAS_5985-38-6 | LEVORPHANOL-tartarate)Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r| Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1 | PDB
UniProtKB/SwissProt
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DrugBank KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50241341
((-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphina...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3CCC4=O)ccc5O |r| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50001707
(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O |TLB:14:12:8.9.10:1.3.2,THB:13:12:8.9.10:1.3.2| Show InChI InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to rat brain opioid receptor |
J Med Chem 21: 101-6 (1978)
Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50000788
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r| Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1 | PDB
UniProtKB/SwissProt
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DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to rat brain opioid receptor |
J Med Chem 21: 101-6 (1978)
Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50367061
(NALORPHINE | NALORPHINE HYDROCHLORIDE)Show SMILES O[C@H]1C=C[C@H]2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45 |r,c:2,TLB:3:4:22.7.6:18.16.17| Show InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1 | PDB
UniProtKB/SwissProt
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KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50367061
(NALORPHINE | NALORPHINE HYDROCHLORIDE)Show SMILES O[C@H]1C=C[C@H]2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45 |r,c:2,TLB:3:4:22.7.6:18.16.17| Show InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1 | PDB
UniProtKB/SwissProt
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KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to rat brain opioid receptor |
J Med Chem 21: 101-6 (1978)
Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50231237
(CHEBI:6125 | Cetobemidone | Cliradon | Cymidon | K...)Show InChI InChI=1S/C15H21NO2/c1-3-14(18)15(7-9-16(2)10-8-15)12-5-4-6-13(17)11-12/h4-6,11,17H,3,7-10H2,1-2H3 | PDB
UniProtKB/SwissProt
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KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to rat brain opioid receptor |
J Med Chem 21: 101-6 (1978)
Article DOI: 10.1021/jm00199a018 BindingDB Entry DOI: 10.7270/Q2J969CM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50452273
(Dihydromorphine)Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(C)CC[C@@]14[C@@]5([H])CC[C@@H]2O)ccc3O |TLB:10:9:14:4.5.6| Show InChI InChI=1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
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DrugBank KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496876
(CHEMBL3228291)Show SMILES CC[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2CCC#N |r,TLB:17:16:2:5.11.4,10:11:2:14.15.16| Show InChI InChI=1S/C18H24N2O/c1-3-15-17-11-13-5-6-14(21)12-16(13)18(15,2)7-10-20(17)9-4-8-19/h5-6,12,15,17,21H,3-4,7,9-11H2,1-2H3/t15-,17?,18-/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496877
(CHEMBL33376)Show SMILES CC1C2Cc3ccc(O)cc3C1(C)CCN2C |TLB:9:10:1:15.13.14| Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3 | PDB
UniProtKB/SwissProt
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496873
(CHEMBL3228292)Show SMILES CC[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2CCC(N)=O |r,TLB:17:16:2:5.11.4,10:11:2:14.15.16| Show InChI InChI=1S/C18H26N2O2/c1-3-14-16-10-12-4-5-13(21)11-15(12)18(14,2)7-9-20(16)8-6-17(19)22/h4-5,11,14,16,21H,3,6-10H2,1-2H3,(H2,19,22)/t14-,16?,18-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496881
(CHEMBL3228683)Show SMILES Cl.[H][C@@]12CCC[C@@]3([H])[C@@]4([H])Cc5cccc(O1)c5[C@@]23CCN4 |r| Show InChI InChI=1S/C16H19NO.ClH/c1-3-10-9-12-11-4-2-6-14-16(11,7-8-17-12)15(10)13(5-1)18-14;/h1,3,5,11-12,14,17H,2,4,6-9H2;1H/t11-,12+,14-,16+;/m0./s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496874
(CHEMBL3228290)Show SMILES CC[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2C |r,TLB:17:16:2:5.11.4,10:11:2:14.15.16| Show InChI InChI=1S/C16H23NO/c1-4-13-15-9-11-5-6-12(18)10-14(11)16(13,2)7-8-17(15)3/h5-6,10,13,15,18H,4,7-9H2,1-3H3/t13-,15?,16-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 15 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496882
(CHEMBL3228681)Show SMILES Cl.[H][C@@]12Oc3cccc4C[C@@]5([H])N(C)CC[C@@]1(c34)[C@@]5([H])CCC2=O |r,THB:13:12:18:17.8.9| Show InChI InChI=1S/C17H19NO2.ClH/c1-18-8-7-17-11-5-6-13(19)16(17)20-14-4-2-3-10(15(14)17)9-12(11)18;/h2-4,11-12,16H,5-9H2,1H3;1H/t11-,12+,16-,17-;/m0./s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496879
(CHEMBL3228679)Show SMILES Cl.[H][C@@]12Oc3cccc4C[C@@]5([H])NCC[C@@]1(c34)[C@@]5([H])CC[C@@H]2O |r| Show InChI InChI=1S/C16H19NO2.ClH/c18-12-5-4-10-11-8-9-2-1-3-13-14(9)16(10,6-7-17-11)15(12)19-13;/h1-3,10-12,15,17-18H,4-8H2;1H/t10-,11+,12-,15-,16-;/m0./s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496880
(CHEMBL3228680)Show SMILES Cl.[H][C@@]12Oc3cccc4C[C@@]5([H])N(C)CC[C@@]1(c34)[C@@]5([H])CC[C@@H]2O |r,THB:13:12:18:17.8.9| Show InChI InChI=1S/C17H21NO2.ClH/c1-18-8-7-17-11-5-6-13(19)16(17)20-14-4-2-3-10(15(14)17)9-12(11)18;/h2-4,11-13,16,19H,5-9H2,1H3;1H/t11-,12+,13-,16-,17-;/m0./s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 90 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50283522
(4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacycl...)Show SMILES CN1CC[C@]23[C@H]4Oc5cccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35 |c:17| Show InChI InChI=1S/C17H19NO2/c1-18-8-7-17-11-5-6-13(19)16(17)20-14-4-2-3-10(15(14)17)9-12(11)18/h2-6,11-13,16,19H,7-9H2,1H3/t11-,12+,13-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496884
(CHEMBL3228682)Show SMILES Cl.[H][C@@]12Oc3cccc4C[C@@]5([H])N(CC=C)CC[C@@]1(c34)[C@@]5([H])CC[C@@H]2O |r,THB:13:12:20:19.8.9| Show InChI InChI=1S/C19H23NO2.ClH/c1-2-9-20-10-8-19-13-6-7-15(21)18(19)22-16-5-3-4-12(17(16)19)11-14(13)20;/h2-5,13-15,18,21H,1,6-11H2;1H/t13-,14+,15-,18-,19-;/m0./s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor in rat brain homogenates |
J Med Chem 22: 256-9 (1979)
Article DOI: 10.1021/jm00189a007 BindingDB Entry DOI: 10.7270/Q2M61P72 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50001707
(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O |TLB:14:12:8.9.10:1.3.2,THB:13:12:8.9.10:1.3.2| Show InChI InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 250 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM82427
(CAS_5985-38-6 | LEVORPHANOL-tartarate)Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r| Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
DrugBank KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50026752
(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)Show InChI InChI=1S/C15H21NO2/c1-3-18-14(17)15(9-11-16(2)12-10-15)13-7-5-4-6-8-13/h4-8H,3,9-12H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496887
(CHEMBL3228707)Show SMILES Oc1ccc2CC3C4CCCC[C@]4(CCN3CCC#N)c2c1 |r,TLB:16:15:4.20.5:7| Show InChI InChI=1S/C19H24N2O/c20-9-3-10-21-11-8-19-7-2-1-4-16(19)18(21)12-14-5-6-15(22)13-17(14)19/h5-6,13,16,18,22H,1-4,7-8,10-12H2/t16?,18?,19-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496875
(CHEMBL3228294)Show InChI InChI=1S/C17H22N2O2/c1-2-16(21)17(14-5-3-6-15(20)13-14)7-11-19(12-8-17)10-4-9-18/h3,5-6,13,20H,2,4,7-8,10-12H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496890
(CHEMBL3228703)Show SMILES C[C@H]1C2Cc3ccc(O)cc3C1(C)CCN2CCC#N |r,TLB:16:15:1:4.10.3,9:10:1:15.14.13| Show InChI InChI=1S/C17H22N2O/c1-12-16-10-13-4-5-14(20)11-15(13)17(12,2)6-9-19(16)8-3-7-18/h4-5,11-12,16,20H,3,6,8-10H2,1-2H3/t12-,16?,17?/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496890
(CHEMBL3228703)Show SMILES C[C@H]1C2Cc3ccc(O)cc3C1(C)CCN2CCC#N |r,TLB:16:15:1:4.10.3,9:10:1:15.14.13| Show InChI InChI=1S/C17H22N2O/c1-12-16-10-13-4-5-14(20)11-15(13)17(12,2)6-9-19(16)8-3-7-18/h4-5,11-12,16,20H,3,6,8-10H2,1-2H3/t12-,16?,17?/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496886
(CHEMBL3228705)Show SMILES C[C@H]1C2Cc3ccc(O)cc3C1(C)CCN2CCCC#N |r,TLB:16:15:1:4.10.3,9:10:1:15.14.13| Show InChI InChI=1S/C18H24N2O/c1-13-17-11-14-5-6-15(21)12-16(14)18(13,2)7-10-20(17)9-4-3-8-19/h5-6,12-13,17,21H,3-4,7,9-11H2,1-2H3/t13-,17?,18?/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496877
(CHEMBL33376)Show SMILES CC1C2Cc3ccc(O)cc3C1(C)CCN2C |TLB:9:10:1:15.13.14| Show InChI InChI=1S/C15H21NO/c1-10-14-8-11-4-5-12(17)9-13(11)15(10,2)6-7-16(14)3/h4-5,9-10,14,17H,6-8H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496891
(CHEMBL3228708)Show SMILES Oc1ccc2CC3C4CCCC[C@]4(CCN3CC#N)c2c1 |r,TLB:16:15:4.19.5:7| Show InChI InChI=1S/C18H22N2O/c19-8-10-20-9-7-18-6-2-1-3-15(18)17(20)11-13-4-5-14(21)12-16(13)18/h4-5,12,15,17,21H,1-3,6-7,9-11H2/t15?,17?,18-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496878
(CHEMBL3228293)Show InChI InChI=1S/C17H22N2O2/c1-2-21-16(20)17(15-7-4-3-5-8-15)9-13-19(14-10-17)12-6-11-18/h3-5,7-8H,2,6,9-10,12-14H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenates |
J Med Chem 22: 889-90 (1979)
Article DOI: 10.1021/jm00193a028 BindingDB Entry DOI: 10.7270/Q2QZ2DXM |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496892
(CHEMBL3228709)Show SMILES [H][C@]12Oc3c4c(CC5C(C=C[C@@H]1O)[C@]24CCN5CCC#N)ccc3O |r,c:9,THB:17:16:5.4.6:8| Show InChI InChI=1S/C19H20N2O3/c20-7-1-8-21-9-6-19-12-3-5-15(23)18(19)24-17-14(22)4-2-11(16(17)19)10-13(12)21/h2-5,12-13,15,18,22-23H,1,6,8-10H2/t12?,13?,15-,18-,19-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496885
(CHEMBL3228704)Show SMILES C[C@H]1C2Cc3ccc(O)cc3C1(C)CCN2CC#N |r,TLB:16:15:1:4.10.3,9:10:1:15.14.13| Show InChI InChI=1S/C16H20N2O/c1-11-15-9-12-3-4-13(19)10-14(12)16(11,2)5-7-18(15)8-6-17/h3-4,10-11,15,19H,5,7-9H2,1-2H3/t11-,15?,16?/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496889
(CHEMBL3228711)Show SMILES [H][C@@]12Oc3c4c(CC5N(CCC#N)CC[C@@]14[C@@]5(O)CCC2=O)ccc3OC |r,THB:9:8:5.4.6:16| Show InChI InChI=1S/C20H22N2O4/c1-25-14-4-3-12-11-15-20(24)6-5-13(23)18-19(20,16(12)17(14)26-18)7-10-22(15)9-2-8-21/h3-4,15,18,24H,2,5-7,9-11H2,1H3/t15?,18-,19-,20+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496888
(CHEMBL3228710)Show SMILES [H][C@]12Oc3c4c(CC5C(C=C[C@@H]1O)[C@]24CCN5CCC#N)ccc3OC |r,c:9,THB:17:16:5.4.6:8| Show InChI InChI=1S/C20H22N2O3/c1-24-16-6-3-12-11-14-13-4-5-15(23)19-20(13,17(12)18(16)25-19)7-10-22(14)9-2-8-21/h3-6,13-15,19,23H,2,7,9-11H2,1H3/t13?,14?,15-,19-,20-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 7.00E+5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50019351
((-)-Codeine | (Codeine) | (codeine)10-methoxy-4-me...)Show SMILES COc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C |r,c:9| Show InChI InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 8.00E+5 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496890
(CHEMBL3228703)Show SMILES C[C@H]1C2Cc3ccc(O)cc3C1(C)CCN2CCC#N |r,TLB:16:15:1:4.10.3,9:10:1:15.14.13| Show InChI InChI=1S/C17H22N2O/c1-12-16-10-13-4-5-14(20)11-15(13)17(12,2)6-9-19(16)8-3-7-18/h4-5,11-12,16,20H,3,6,8-10H2,1-2H3/t12-,16?,17?/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+8 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |
Delta-type/Kappa-type/Mu-type opioid receptor
(Rattus norvegicus (rat)) | BDBM50496887
(CHEMBL3228707)Show SMILES Oc1ccc2CC3C4CCCC[C@]4(CCN3CCC#N)c2c1 |r,TLB:16:15:4.20.5:7| Show InChI InChI=1S/C19H24N2O/c20-9-3-10-21-11-8-19-7-2-1-4-16(19)18(21)12-14-5-6-15(22)13-17(14)19/h5-6,13,16,18,22H,1-4,7-8,10-12H2/t16?,18?,19-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+8 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opiate receptor in rat brain homogenates |
J Med Chem 22: 328-31 (1979)
Article DOI: 10.1021/jm00189a024 BindingDB Entry DOI: 10.7270/Q2GH9MX3 |
More data for this Ligand-Target Pair | |