Found 8 hits of ec50 for UniProtKB: P02708 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human)) | BDBM50459884
(CHEMBL4228846)Show InChI InChI=1S/C14H15BrN2OS/c15-11-5-1-3-9-7-12(19-13(9)11)14(18)17-10-4-2-6-16-8-10/h1,3,5,7,10,16H,2,4,6,8H2,(H,17,18)/t10-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 286 | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Positive allosteric modulation of human alpha2beta4 nAChR expressed in HEK cells preincubated for 15 mins followed by dihydro-beta-erythroidine hydro... |
Bioorg Med Chem Lett 27: 3207-3218 (2017)
Article DOI: 10.1016/j.bmcl.2017.04.073 BindingDB Entry DOI: 10.7270/Q2MC92NR |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human)) | BDBM50052593
(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by PDSP Ki Database
| Assay Description The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... |
J Med Chem 39: 3235-7 (1996)
Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human)) | BDBM50052593
(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by PDSP Ki Database
| Assay Description The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... |
J Med Chem 39: 3235-7 (1996)
Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human)) | BDBM50369150
(CHEMBL1788226)Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by PDSP Ki Database
| Assay Description Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes. |
J Med Chem 39: 3235-7 (1996)
Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human)) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by PDSP Ki Database
| Assay Description The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... |
J Med Chem 39: 3235-7 (1996)
Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human)) | BDBM86544
(CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...)Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by PDSP Ki Database
| Assay Description The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona... |
J Med Chem 39: 3235-7 (1996)
Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human)) | BDBM86544
(CAS_192231-16-6 | CHEMBL111580 | NSC_6442277 | SIB...)Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by PDSP Ki Database
| Assay Description Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes. |
J Med Chem 39: 3235-7 (1996)
Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4
(Homo sapiens (Human)) | BDBM50369150
(CHEMBL1788226)Show InChI InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a |
SIBIA Neurosciences Inc.
Curated by PDSP Ki Database
| Assay Description Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes. |
J Med Chem 39: 3235-7 (1996)
Article DOI: 10.1021/jm960328w BindingDB Entry DOI: 10.7270/Q2BV7H97 |
More data for this Ligand-Target Pair | |