Found 22 hits of ec50 for UniProtKB: P11309 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518520
(CHEMBL4593810)Show SMILES CC(O)C#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O |r| Show InChI InChI=1S/C17H18Cl2N4O2/c1-9(24)4-5-13-15(19)14-11(18)7-12(16(20)25)22-17(14)23(13)10-3-2-6-21-8-10/h7,9-10,21,24H,2-3,6,8H2,1H3,(H2,20,25)/t9?,10-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518510
(CHEMBL4448325)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CCCO)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C17H18Cl2N4O2/c18-11-8-12(16(20)25)22-17-14(11)15(19)13(5-1-2-7-24)23(17)10-4-3-6-21-9-10/h8,10,21,24H,2-4,6-7,9H2,(H2,20,25)/t10-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518517
(CHEMBL4540910)Show SMILES COCCC#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O |r| Show InChI InChI=1S/C18H20Cl2N4O2/c1-26-8-3-2-6-14-16(20)15-12(19)9-13(17(21)25)23-18(15)24(14)11-5-4-7-22-10-11/h9,11,22H,3-5,7-8,10H2,1H3,(H2,21,25)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518521
(CHEMBL4564586)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C18H18Cl2N4O/c19-12-8-13(17(21)25)23-18-15(12)16(20)14(6-5-10-3-4-10)24(18)11-2-1-7-22-9-11/h8,10-11,22H,1-4,7,9H2,(H2,21,25)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518506
(CHEMBL4588948)Show SMILES CC(O)CC#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O |r| Show InChI InChI=1S/C18H20Cl2N4O2/c1-10(25)4-2-6-14-16(20)15-12(19)8-13(17(21)26)23-18(15)24(14)11-5-3-7-22-9-11/h8,10-11,22,25H,3-5,7,9H2,1H3,(H2,21,26)/t10?,11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518519
(CHEMBL4457389)Show SMILES CC1(CC#Cc2c(Cl)c3c(Cl)cc(nc3n2[C@H]2CCCNC2)C(N)=O)COC1 |r| Show InChI InChI=1S/C20H22Cl2N4O2/c1-20(10-28-11-20)6-2-5-15-17(22)16-13(21)8-14(18(23)27)25-19(16)26(15)12-4-3-7-24-9-12/h8,12,24H,3-4,6-7,9-11H2,1H3,(H2,23,27)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 33 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518509
(CHEMBL4587382)Show SMILES CC(C)(O)C#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O |r| Show InChI InChI=1S/C18H20Cl2N4O2/c1-18(2,26)6-5-13-15(20)14-11(19)8-12(16(21)25)23-17(14)24(13)10-4-3-7-22-9-10/h8,10,22,26H,3-4,7,9H2,1-2H3,(H2,21,25)/t10-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 36 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518518
(CHEMBL4470576)Show SMILES CC1(COC1)C#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O |r| Show InChI InChI=1S/C19H20Cl2N4O2/c1-19(9-27-10-19)5-4-14-16(21)15-12(20)7-13(17(22)26)24-18(15)25(14)11-3-2-6-23-8-11/h7,11,23H,2-3,6,8-10H2,1H3,(H2,22,26)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518513
(CHEMBL4528544)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCOCC3)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C20H22Cl2N4O2/c21-14-10-15(19(23)27)25-20-17(14)18(22)16(4-3-12-5-8-28-9-6-12)26(20)13-2-1-7-24-11-13/h10,12-13,24H,1-2,5-9,11H2,(H2,23,27)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518522
(CHEMBL4466080)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CCO)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C16H16Cl2N4O2/c17-10-7-11(15(19)24)21-16-13(10)14(18)12(4-2-6-23)22(16)9-3-1-5-20-8-9/h7,9,20,23H,1,3,5-6,8H2,(H2,19,24)/t9-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 59 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518512
(CHEMBL4541837)Show SMILES COC(C)(C)CC#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O |r| Show InChI InChI=1S/C20H24Cl2N4O2/c1-20(2,28-3)8-4-7-15-17(22)16-13(21)10-14(18(23)27)25-19(16)26(15)12-6-5-9-24-11-12/h10,12,24H,5-6,8-9,11H2,1-3H3,(H2,23,27)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 61 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518504
(CHEMBL4466764)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3COCCO3)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C19H20Cl2N4O3/c20-13-8-14(18(22)26)24-19-16(13)17(21)15(4-3-12-10-27-6-7-28-12)25(19)11-2-1-5-23-9-11/h8,11-12,23H,1-2,5-7,9-10H2,(H2,22,26)/t11-,12?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518504
(CHEMBL4466764)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3COCCO3)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C19H20Cl2N4O3/c20-13-8-14(18(22)26)24-19-16(13)17(21)15(4-3-12-10-27-6-7-28-12)25(19)11-2-1-5-23-9-11/h8,11-12,23H,1-2,5-7,9-10H2,(H2,22,26)/t11-,12?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518516
(CHEMBL4445116)Show SMILES CC(C)(CC#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O)C#N |r| Show InChI InChI=1S/C20H21Cl2N5O/c1-20(2,11-23)7-3-6-15-17(22)16-13(21)9-14(18(24)28)26-19(16)27(15)12-5-4-8-25-10-12/h9,12,25H,4-5,7-8,10H2,1-2H3,(H2,24,28)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 90 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518515
(CHEMBL4446498)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CCN3CCCC3=O)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C20H21Cl2N5O2/c21-13-10-14(19(23)29)25-20-17(13)18(22)15(27(20)12-4-1-7-24-11-12)5-2-8-26-9-3-6-16(26)28/h10,12,24H,1,3-4,6-9,11H2,(H2,23,29)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 93 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518511
(CHEMBL4457529)Show SMILES COCC(C)(C)C#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O |r| Show InChI InChI=1S/C20H24Cl2N4O2/c1-20(2,11-28-3)7-6-15-17(22)16-13(21)9-14(18(23)27)25-19(16)26(15)12-5-4-8-24-10-12/h9,12,24H,4-5,8,10-11H2,1-3H3,(H2,23,27)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 98 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518514
(CHEMBL4563802)Show SMILES CN1CC(CC1=O)C#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O |r| Show InChI InChI=1S/C20H21Cl2N5O2/c1-26-10-11(7-16(26)28)4-5-15-18(22)17-13(21)8-14(19(23)29)25-20(17)27(15)12-3-2-6-24-9-12/h8,11-12,24H,2-3,6-7,9-10H2,1H3,(H2,23,29)/t11?,12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 128 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518508
(CHEMBL4533366)Show SMILES CC(C)(CC#Cc1c(Cl)c2c(Cl)cc(nc2n1[C@H]1CCCNC1)C(N)=O)C(N)=O |r| Show InChI InChI=1S/C20H23Cl2N5O2/c1-20(2,19(24)29)7-3-6-14-16(22)15-12(21)9-13(17(23)28)26-18(15)27(14)11-5-4-8-25-10-11/h9,11,25H,4-5,7-8,10H2,1-2H3,(H2,23,28)(H2,24,29)/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 133 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518505
(CHEMBL4518492)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C19H20Cl2N4O2/c20-13-9-14(18(22)26)24-19-16(13)17(21)15(6-5-12-4-2-8-27-12)25(19)11-3-1-7-23-10-11/h9,11-12,23H,1-4,7-8,10H2,(H2,22,26)/t11-,12?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 137 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518505
(CHEMBL4518492)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C19H20Cl2N4O2/c20-13-9-14(18(22)26)24-19-16(13)17(21)15(6-5-12-4-2-8-27-12)25(19)11-3-1-7-23-10-11/h9,11-12,23H,1-4,7-8,10H2,(H2,22,26)/t11-,12?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 137 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518507
(CHEMBL4583118)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CNCCO3)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C19H21Cl2N5O2/c20-13-8-14(18(22)27)25-19-16(13)17(21)15(4-3-12-10-24-6-7-28-12)26(19)11-2-1-5-23-9-11/h8,11-12,23-24H,1-2,5-7,9-10H2,(H2,22,27)/t11-,12?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 283 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50518507
(CHEMBL4583118)Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CNCCO3)n([C@H]3CCCNC3)c2n1 |r| Show InChI InChI=1S/C19H21Cl2N5O2/c20-13-8-14(18(22)27)25-19-16(13)17(21)15(4-3-12-10-24-6-7-28-12)26(19)11-2-1-5-23-9-11/h8,11-12,23-24H,1-2,5-7,9-10H2,(H2,22,27)/t11-,12?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 283 | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of PIM in human KG1 cells assessed as reduction in pS6 level |
Bioorg Med Chem Lett 29: 491-495 (2019)
Article DOI: 10.1016/j.bmcl.2018.12.015
BindingDB Entry DOI: 10.7270/Q21V5J93 |
More data for this
Ligand-Target Pair | |
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