Found 362 hits of ic50 for UniProtKB: P34975 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225205
(CHEMBL540269)Show SMILES Br.[H][C@@]12Oc3c4c(CC5N(C)CC[C@@]14[C@]5(CCC2=O)OC)ccc3O |r,THB:10:9:14:5.6.7| Show InChI InChI=1S/C18H21NO4.BrH/c1-19-8-7-17-14-10-3-4-11(20)15(14)23-16(17)12(21)5-6-18(17,22-2)13(19)9-10;/h3-4,13,16,20H,5-9H2,1-2H3;1H/t13?,16-,17-,18+;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50017233
(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)Show SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc31 |r,TLB:0:1:12.18.11:9| Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description 50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate |
J Med Chem 28: 1177-80 (1985)
BindingDB Entry DOI: 10.7270/Q2X350PW |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000788
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r| Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000788
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r| Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.00900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50001707
(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O |TLB:14:12:8.9.10:1.3.2,THB:13:12:8.9.10:1.3.2| Show InChI InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225845
(CHEMBL293967)Show SMILES Oc1ccc2CC3N(CC4CC4)CCC45C(Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\C(=O)OCCc1ccccc1 |TLB:23:22:18.4.5:7.13.12,THB:17:18:22:7.13.12,8:7:22:18.4.5| Show InChI InChI=1S/C32H36N2O6/c35-24-9-8-22-18-25-32(38)14-12-23(33-26(36)10-11-27(37)39-17-13-20-4-2-1-3-5-20)30-31(32,28(22)29(24)40-30)15-16-34(25)19-21-6-7-21/h1-5,8-11,21,23,25,30,35,38H,6-7,12-19H2,(H,33,36)/b11-10+/t23-,25?,30?,31?,32-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligand |
J Med Chem 29: 1868-71 (1986)
BindingDB Entry DOI: 10.7270/Q2D50Q50 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225204
(CHEMBL606711)Show SMILES [H][C@]12Cc3cccc(O)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,THB:14:13:20:9.3.2| Show InChI InChI=1S/C18H23NO3/c1-19-9-8-17-11-13(20)6-7-18(17,22-2)15(19)10-12-4-3-5-14(21)16(12)17/h3-5,15,21H,6-11H2,1-2H3/t15-,17-,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description 50% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate |
J Med Chem 28: 1177-80 (1985)
BindingDB Entry DOI: 10.7270/Q2X350PW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225205
(CHEMBL540269)Show SMILES Br.[H][C@@]12Oc3c4c(CC5N(C)CC[C@@]14[C@]5(CCC2=O)OC)ccc3O |r,THB:10:9:14:5.6.7| Show InChI InChI=1S/C18H21NO4.BrH/c1-19-8-7-17-14-10-3-4-11(20)15(14)23-16(17)12(21)5-6-18(17,22-2)13(19)9-10;/h3-4,13,16,20H,5-9H2,1-2H3;1H/t13?,16-,17-,18+;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225211
(CHEMBL606767)Show SMILES [H][C@]12Cc3ccc(OC)c(OC)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,THB:17:16:23:12.3.2| Show InChI InChI=1S/C20H27NO4/c1-21-10-9-19-12-14(22)7-8-20(19,25-4)16(21)11-13-5-6-15(23-2)18(24-3)17(13)19/h5-6,16H,7-12H2,1-4H3/t16-,19-,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.0850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50001707
(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@]3(O)CCC4=O)ccc5O |TLB:14:12:8.9.10:1.3.2,THB:13:12:8.9.10:1.3.2| Show InChI InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225213
(CHEMBL606820)Show SMILES [H][C@]12Cc3ccccc3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,TLB:18:19:8.2.3:12.10.11,20:19:8.2.3:12.10.11,13:12:19:8.2.3,THB:7:8:19:12.10.11| Show InChI InChI=1S/C18H23NO2/c1-19-10-9-17-12-14(20)7-8-18(17,21-2)16(19)11-13-5-3-4-6-15(13)17/h3-6,16H,7-12H2,1-2H3/t16-,17-,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225206
(CHEMBL606643)Show SMILES [H][C@]12Cc3cccc(O)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23O |r,THB:14:13:20:9.3.2| Show InChI InChI=1S/C17H21NO3/c1-18-8-7-16-10-12(19)5-6-17(16,21)14(18)9-11-3-2-4-13(20)15(11)16/h2-4,14,20-21H,5-10H2,1H3/t14-,16-,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50326670
(17-methoxy-4-methyl-(13R,17S)-12-oxa-4-azapentacyc...)Show SMILES CO[C@]12CCC(=O)[C@@H]3Oc4cccc5C[C@H]1N(C)CC[C@@]23c45 |r| Show InChI InChI=1S/C18H21NO3/c1-19-9-8-17-15-11-4-3-5-13(15)22-16(17)12(20)6-7-18(17,21-2)14(19)10-11/h3-5,14,16H,6-10H2,1-2H3/t14-,16+,17+,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50027473
(3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-pi...)Show SMILES CCC(=O)N(c1ccccc1)[C@]1(CCN(CCc2ccccc2)C[C@H]1C)C(=O)OC Show InChI InChI=1S/C25H32N2O3/c1-4-23(28)27(22-13-9-6-10-14-22)25(24(29)30-3)16-18-26(19-20(25)2)17-15-21-11-7-5-8-12-21/h5-14,20H,4,15-19H2,1-3H3/t20-,25+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL DrugBank PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]nalotrexone from rat-brain Opioid receptors |
J Med Chem 25: 913-9 (1982)
BindingDB Entry DOI: 10.7270/Q2CF9S9G |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50326659
(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)Show SMILES COc1cccc2C[C@H]3N(C)CC[C@@]4(CC(=O)CC[C@@]34OC)c12 |r| Show InChI InChI=1S/C19H25NO3/c1-20-10-9-18-12-14(21)7-8-19(18,23-3)16(20)11-13-5-4-6-15(22-2)17(13)18/h4-6,16H,7-12H2,1-3H3/t16-,18-,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50013184
(1H-Indole-2-carboxylic acid [5-(2-fluoro-phenyl)-1...)Show SMILES CN1C(CNC(=O)c2cc3ccccc3[nH]2)CN=C(c2ccccc2F)c2ccccc12 |t:19| Show InChI InChI=1S/C26H23FN4O/c1-31-18(16-29-26(32)23-14-17-8-2-6-12-22(17)30-23)15-28-25(19-9-3-5-11-21(19)27)20-10-4-7-13-24(20)31/h2-14,18,30H,15-16H2,1H3,(H,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]dihydromorphine (DHM) from rat brain Opioid receptors |
J Med Chem 33: 450-5 (1990)
BindingDB Entry DOI: 10.7270/Q26M35TN |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225848
(CHEMBL53563)Show SMILES Oc1ccc2CC3N(CC4CC4)CCC45C(Oc1c24)[C@@H](CC[C@@]35O)NC(=O)\C=C\C(=O)OCc1ccccc1 |TLB:23:22:18.4.5:7.13.12,THB:17:18:22:7.13.12,8:7:22:18.4.5| Show InChI InChI=1S/C31H34N2O6/c34-23-9-8-21-16-24-31(37)13-12-22(32-25(35)10-11-26(36)38-18-20-4-2-1-3-5-20)29-30(31,27(21)28(23)39-29)14-15-33(24)17-19-6-7-19/h1-5,8-11,19,22,24,29,34,37H,6-7,12-18H2,(H,32,35)/b11-10+/t22-,24?,29?,30?,31-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligand |
J Med Chem 29: 1868-71 (1986)
BindingDB Entry DOI: 10.7270/Q2D50Q50 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225214
(CHEMBL606769)Show SMILES [H][C@]12Cc3ccccc3[C@@]3(CCN1C)CC(=O)CC[C@@]23O |r,TLB:18:19:8.2.3:12.10.11,20:19:8.2.3:12.10.11,13:12:19:8.2.3,THB:7:8:19:12.10.11| Show InChI InChI=1S/C17H21NO2/c1-18-9-8-16-11-13(19)6-7-17(16,20)15(18)10-12-4-2-3-5-14(12)16/h2-5,15,20H,6-11H2,1H3/t15-,16-,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224339
(CHEMBL1744167)Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(CC#C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1 Show InChI InChI=1S/C26H31ClN2O3.C4H4O4/c1-4-16-29(23-11-7-8-12-24(23)32-3)25(30)20(2)26(31)14-18-28(19-15-26)17-13-21-9-5-6-10-22(21)27;5-3(6)1-2-4(7)8/h1,5-12,20,31H,13-19H2,2-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224336
(CHEMBL1744168)Show SMILES OC(=O)\C=C/C(O)=O.COc1ccccc1N(CC=C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1 Show InChI InChI=1S/C26H33ClN2O3.C4H4O4/c1-4-16-29(23-11-7-8-12-24(23)32-3)25(30)20(2)26(31)14-18-28(19-15-26)17-13-21-9-5-6-10-22(21)27;5-3(6)1-2-4(7)8/h4-12,20,31H,1,13-19H2,2-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50354578
(BUPRENORPHINE | US10752592, Compound buprenorphine...)Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 |r| Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50354578
(BUPRENORPHINE | US10752592, Compound buprenorphine...)Show SMILES CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45 |r| Show InChI InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl. |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50226933
(Naltrexonazine)Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC\C2=N/N=C1\CC[C@@]2(O)[C@@]4([H])Cc5ccc(O)c6O[C@]1([H])[C@]2(CCN4CC1CC1)c56)ccc3O |r,TLB:45:44:32.49.31:27,THB:10:9:17:6.5.4| Show InChI InChI=1S/C40H46N4O6/c45-27-7-5-23-17-29-39(47)11-9-25(35-37(39,31(23)33(27)49-35)13-15-43(29)19-21-1-2-21)41-42-26-10-12-40(48)30-18-24-6-8-28(46)34-32(24)38(40,36(26)50-34)14-16-44(30)20-22-3-4-22/h5-8,21-22,29-30,35-36,45-48H,1-4,9-20H2/b41-25+,42-26+/t29-,30-,35+,36+,37+,38+,39-,40-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptor |
J Med Chem 30: 1489-94 (1987)
BindingDB Entry DOI: 10.7270/Q2S46V6F |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50226933
(Naltrexonazine)Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC\C2=N/N=C1\CC[C@@]2(O)[C@@]4([H])Cc5ccc(O)c6O[C@]1([H])[C@]2(CCN4CC1CC1)c56)ccc3O |r,TLB:45:44:32.49.31:27,THB:10:9:17:6.5.4| Show InChI InChI=1S/C40H46N4O6/c45-27-7-5-23-17-29-39(47)11-9-25(35-37(39,31(23)33(27)49-35)13-15-43(29)19-21-1-2-21)41-42-26-10-12-40(48)30-18-24-6-8-28(46)34-32(24)38(40,36(26)50-34)14-16-44(30)20-22-3-4-22/h5-8,21-22,29-30,35-36,45-48H,1-4,9-20H2/b41-25+,42-26+/t29-,30-,35+,36+,37+,38+,39-,40-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptor |
J Med Chem 30: 1489-94 (1987)
BindingDB Entry DOI: 10.7270/Q2S46V6F |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50226933
(Naltrexonazine)Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC\C2=N/N=C1\CC[C@@]2(O)[C@@]4([H])Cc5ccc(O)c6O[C@]1([H])[C@]2(CCN4CC1CC1)c56)ccc3O |r,TLB:45:44:32.49.31:27,THB:10:9:17:6.5.4| Show InChI InChI=1S/C40H46N4O6/c45-27-7-5-23-17-29-39(47)11-9-25(35-37(39,31(23)33(27)49-35)13-15-43(29)19-21-1-2-21)41-42-26-10-12-40(48)30-18-24-6-8-28(46)34-32(24)38(40,36(26)50-34)14-16-44(30)20-22-3-4-22/h5-8,21-22,29-30,35-36,45-48H,1-4,9-20H2/b41-25+,42-26+/t29-,30-,35+,36+,37+,38+,39-,40-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]DAMPGO binding was determined using standard binding assay in rat brain homogenates against opioid receptor |
J Med Chem 30: 1489-94 (1987)
BindingDB Entry DOI: 10.7270/Q2S46V6F |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM60212
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description Inhibition of [3H]naloxone binding to opioid receptor in presence of NaCl |
J Med Chem 32: 418-21 (1989)
BindingDB Entry DOI: 10.7270/Q2ZG6VG1 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225212
(CHEMBL606707)Show SMILES [H][C@]12Cc3ccc(OC)c(O)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,THB:16:15:22:11.3.2| Show InChI InChI=1S/C19H25NO4/c1-20-9-8-18-11-13(21)6-7-19(18,24-3)15(20)10-12-4-5-14(23-2)17(22)16(12)18/h4-5,15,22H,6-11H2,1-3H3/t15-,18-,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50013209
(4-Chloro-N-[5-(2-fluoro-phenyl)-1-methyl-2,3-dihyd...)Show SMILES CN1C(CNC(=O)c2ccc(Cl)cc2)CN=C(c2ccccc2F)c2ccccc12 |t:16| Show InChI InChI=1S/C24H21ClFN3O/c1-29-18(15-28-24(30)16-10-12-17(25)13-11-16)14-27-23(19-6-2-4-8-21(19)26)20-7-3-5-9-22(20)29/h2-13,18H,14-15H2,1H3,(H,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of binding of [125I]-CCK-8 to Cholecystokinin type A receptor in rat pancreas |
J Med Chem 33: 450-5 (1990)
BindingDB Entry DOI: 10.7270/Q26M35TN |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225232
(CHEMBL606768)Show SMILES [H][C@]12Cc3ccc(OC)c(OC)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23O |r,THB:17:16:23:12.3.2| Show InChI InChI=1S/C19H25NO4/c1-20-9-8-18-11-13(21)6-7-19(18,22)15(20)10-12-4-5-14(23-2)17(24-3)16(12)18/h4-5,15,22H,6-11H2,1-3H3/t15-,18-,19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224323
(CHEMBL1794881)Show SMILES OC(=O)\C=C\C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC Show InChI InChI=1S/C26H35ClN2O3.C4H4O4/c1-4-16-29(23-11-7-8-12-24(23)32-3)25(30)20(2)26(31)14-18-28(19-15-26)17-13-21-9-5-6-10-22(21)27;5-3(6)1-2-4(7)8/h5-12,20,31H,4,13-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224340
(CHEMBL147150)Show SMILES CCOc1ccccc1N(CC)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1 Show InChI InChI=1S/C26H35ClN2O3/c1-4-29(23-12-8-9-13-24(23)32-5-2)25(30)20(3)26(31)15-18-28(19-16-26)17-14-21-10-6-7-11-22(21)27/h6-13,20,31H,4-5,14-19H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50021347
(CHEMBL12391 | N-(3-Methyl-1-phenethyl-piperidin-4-...)Show SMILES CCC(=O)N([C@H]1CCN(CCc2ccccc2)C[C@H]1C)c1ccccc1 Show InChI InChI=1S/C23H30N2O/c1-3-23(26)25(21-12-8-5-9-13-21)22-15-17-24(18-19(22)2)16-14-20-10-6-4-7-11-20/h4-13,19,22H,3,14-18H2,1-2H3/t19-,22+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement [3H]naloxone from rat-brain Opioid receptors |
J Med Chem 25: 913-9 (1982)
BindingDB Entry DOI: 10.7270/Q2CF9S9G |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224315
(CHEMBL2304164)Show SMILES [H][C@]1(CCN(CCc2ccccc2)C[C@@H]1C)N(C(=O)C=[N+]=[N-])c1ccccc1 Show InChI InChI=1S/C22H26N4O/c1-18-17-25(14-12-19-8-4-2-5-9-19)15-13-21(18)26(22(27)16-24-23)20-10-6-3-7-11-20/h2-11,16,18,21H,12-15,17H2,1H3/t18-,21+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement [3H]naloxone from rat-brain Opioid receptors |
J Med Chem 25: 913-9 (1982)
BindingDB Entry DOI: 10.7270/Q2CF9S9G |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM60212
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck
Curated by ChEMBL
| Assay Description Inhibition of [3H]naloxone binding to opioid receptor in presence of NaCl |
J Med Chem 32: 418-21 (1989)
BindingDB Entry DOI: 10.7270/Q2ZG6VG1 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225849
(CHEMBL301654)Show SMILES CCOC(=O)\C=C\C(=O)N[C@@H]1CC[C@@]2(O)C3Cc4ccc(O)c5OC1C2(CCN3CC1CC1)c45 |TLB:22:33:13:28.26.27,14:13:33.17.16:28.26.27,29:28:13:33.17.16| Show InChI InChI=1S/C26H32N2O6/c1-2-33-21(31)8-7-20(30)27-17-9-10-26(32)19-13-16-5-6-18(29)23-22(16)25(26,24(17)34-23)11-12-28(19)14-15-3-4-15/h5-8,15,17,19,24,29,32H,2-4,9-14H2,1H3,(H,27,30)/b8-7+/t17-,19?,24?,25?,26-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligand |
J Med Chem 29: 1868-71 (1986)
BindingDB Entry DOI: 10.7270/Q2D50Q50 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224323
(CHEMBL1794881)Show SMILES OC(=O)\C=C\C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC Show InChI InChI=1S/C26H35ClN2O3.C4H4O4/c1-4-16-29(23-11-7-8-12-24(23)32-3)25(30)20(2)26(31)14-18-28(19-15-26)17-13-21-9-5-6-10-22(21)27;5-3(6)1-2-4(7)8/h5-12,20,31H,4,13-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl. |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225204
(CHEMBL606711)Show SMILES [H][C@]12Cc3cccc(O)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,THB:14:13:20:9.3.2| Show InChI InChI=1S/C18H23NO3/c1-19-9-8-17-11-13(20)6-7-18(17,22-2)15(19)10-12-4-3-5-14(21)16(12)17/h3-5,15,21H,6-11H2,1-2H3/t15-,17-,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225208
(CHEMBL606819)Show SMILES [H][C@]12Cc3cccc(OC)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23O |r,THB:15:14:21:10.3.2| Show InChI InChI=1S/C18H23NO3/c1-19-9-8-17-11-13(20)6-7-18(17,21)15(19)10-12-4-3-5-14(22-2)16(12)17/h3-5,15,21H,6-11H2,1-2H3/t15-,17-,18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50000092
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1| Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224341
(CHEMBL1744169)Show SMILES OC(=O)\C=C/C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OCC Show InChI InChI=1S/C27H37ClN2O3.C4H4O4/c1-4-17-30(24-12-8-9-13-25(24)33-5-2)26(31)21(3)27(32)15-19-29(20-16-27)18-14-22-10-6-7-11-23(22)28;5-3(6)1-2-4(7)8/h6-13,21,32H,4-5,14-20H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225207
(CHEMBL553032)Show SMILES Br.[H][C@@]12Oc3c4c(CC5N(C)CC[C@@]14[C@]5(CCC2=O)OC)ccc3OCc1ccccc1 |r,THB:10:9:14:5.6.7| Show InChI InChI=1S/C25H27NO4.BrH/c1-26-13-12-24-21-17-8-9-19(29-15-16-6-4-3-5-7-16)22(21)30-23(24)18(27)10-11-25(24,28-2)20(26)14-17;/h3-9,20,23H,10-15H2,1-2H3;1H/t20?,23-,24-,25+;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50223629
(CHEMBL351642)Show InChI InChI=1S/C23H30N2O2/c1-3-23(26)25(21-11-7-8-12-22(21)27-2)20-14-17-24(18-15-20)16-13-19-9-5-4-6-10-19/h4-12,20H,3,13-18H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.840 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptors by the displacement of [3H]fentanyl in rat brain homogenates |
J Med Chem 24: 777-82 (1981)
BindingDB Entry DOI: 10.7270/Q2BP050P |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50225211
(CHEMBL606767)Show SMILES [H][C@]12Cc3ccc(OC)c(OC)c3[C@@]3(CCN1C)CC(=O)CC[C@@]23OC |r,THB:17:16:23:12.3.2| Show InChI InChI=1S/C20H27NO4/c1-21-10-9-19-12-14(22)7-8-20(19,25-4)16(21)11-13-5-6-15(23-2)18(24-3)17(13)19/h5-6,16H,7-12H2,1-4H3/t16-,19-,20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaCl |
J Med Chem 27: 1575-9 (1984)
BindingDB Entry DOI: 10.7270/Q2X92DHJ |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224322
(CHEMBL1744170)Show SMILES OC(=O)\C=C\C(O)=O.CCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OC Show InChI InChI=1S/C25H33ClN2O3.C4H4O4/c1-4-28(22-11-7-8-12-23(22)31-3)24(29)19(2)25(30)14-17-27(18-15-25)16-13-20-9-5-6-10-21(20)26;5-3(6)1-2-4(7)8/h5-12,19,30H,4,13-18H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224341
(CHEMBL1744169)Show SMILES OC(=O)\C=C/C(O)=O.CCCN(C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1)c1ccccc1OCC Show InChI InChI=1S/C27H37ClN2O3.C4H4O4/c1-4-17-30(24-12-8-9-13-25(24)33-5-2)26(31)21(3)27(32)15-19-29(20-16-27)18-14-22-10-6-7-11-23(22)28;5-3(6)1-2-4(7)8/h6-13,21,32H,4-5,14-20H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl. |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50224320
(CHEMBL1744186)Show SMILES OC(=O)\C=C\C(O)=O.CCOc1ccccc1N(C)C(=O)C(C)C1(O)CCN(CCc2ccccc2Cl)CC1 Show InChI InChI=1S/C25H33ClN2O3.C4H4O4/c1-4-31-23-12-8-7-11-22(23)27(3)24(29)19(2)25(30)14-17-28(18-15-25)16-13-20-9-5-6-10-21(20)26;5-3(6)1-2-4(7)8/h5-12,19,30H,4,13-18H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl |
J Med Chem 26: 42-50 (1983)
BindingDB Entry DOI: 10.7270/Q23X88VD |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50247803
(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)Show SMILES COC(=O)\C=C\C(=O)N[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45 |r| Show InChI InChI=1S/C25H30N2O6/c1-32-20(30)7-6-19(29)26-16-8-9-25(31)18-12-15-4-5-17(28)22-21(15)24(25,23(16)33-22)10-11-27(18)13-14-2-3-14/h4-7,14,16,18,23,28,31H,2-3,8-13H2,1H3,(H,26,29)/b7-6+/t16-,18-,23+,24+,25-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was tested for binding affinity against opioid receptor in rat brain membranes, using [3H]dihydromorphine as the radioligand |
J Med Chem 29: 1868-71 (1986)
BindingDB Entry DOI: 10.7270/Q2D50Q50 |
More data for this Ligand-Target Pair | |
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1
(Rattus norvegicus (rat)-RAT) | BDBM50452659
(CHEMBL304546)Show SMILES CN1[C@H](CNC(=O)c2ccc(C)cc2)CN=C(c2ccc(F)cc2)c2ccc(C)cc12 |t:16| Show InChI InChI=1S/C26H26FN3O/c1-17-4-7-20(8-5-17)26(31)29-16-22-15-28-25(19-9-11-21(27)12-10-19)23-13-6-18(2)14-24(23)30(22)3/h4-14,22H,15-16H2,1-3H3,(H,29,31)/t22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Evaluated for its concentration required for displacement of [3H]-Naloxone from opioid receptors in rat brain tissues |
J Med Chem 33: 450-5 (1990)
BindingDB Entry DOI: 10.7270/Q26M35TN |
More data for this Ligand-Target Pair | |