Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM6619 (3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 71 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Banyu Tsukuba Research Institute | Assay Description In vitro kinase assays using synthetic peptides and purified enzymes were incubated at 30°C for 20 min in buffer that contained 50 uM ATP, and d... | J Med Chem 44: 4628-40 (2001) Article DOI: 10.1021/jm010326y BindingDB Entry DOI: 10.7270/Q2BV7DS8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472681 (2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472683 (N-(5-(4-methylpiperazin-1- yl)pyridin-2-yl)-8',9'-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472682 (US10829490, Cmpd # 8 | ethyl 2-((5-(4-methylpipera...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472673 (10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472680 (2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472677 (2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472675 (2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472674 (10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] (Homo sapiens (Human)) | BDBM472678 (2'-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
GI Therapeutics, Inc. US Patent | Assay Description Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ... | US Patent US10829490 (2020) BindingDB Entry DOI: 10.7270/Q20V8GV8 | |||||||||||
More data for this Ligand-Target Pair |