Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Wee1-like protein kinase (Homo sapiens (Human)) | BDBM50043654 (CHEMBL3355539) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Global Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of WEE1 in human NCI-H1299 cells assessed as reduction in Cdc2 phosphorylation at Tyr15 residue measured after 6 hrs by ELISA | Bioorg Med Chem Lett 29: 1481-1486 (2019) Article DOI: 10.1016/j.bmcl.2019.04.017 BindingDB Entry DOI: 10.7270/Q2VX0KXT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Wee1-like protein kinase (Homo sapiens (Human)) | BDBM50043654 (CHEMBL3355539) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
AbbVie Curated by ChEMBL | Assay Description Inhibition of human Weel1 in human NCI-H1299 cells assessed as phosphorylation of Cdk1 after overnight incubation by ELISA PD assay | ACS Med Chem Lett 6: 58-62 (2015) Article DOI: 10.1021/ml5002745 BindingDB Entry DOI: 10.7270/Q2NZ8972 | |||||||||||
More data for this Ligand-Target Pair |