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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Curated by ChEMBL | Assay Description Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization... | Bioorg Med Chem Lett 27: 2571-2574 (2017) Article DOI: 10.1016/j.bmcl.2017.03.082 BindingDB Entry DOI: 10.7270/Q2571F44 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Induced myeloid leukemia cell differentiation protein Mcl-1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay | Assay Description NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q23X8539 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity towards rat Dopamine receptor D2 by [3H]-spiperone displacement. | J Med Chem 33: 600-7 (1990) BindingDB Entry DOI: 10.7270/Q2XS5TCP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| M18 aspartyl aminopeptidase (Plasmodium falciparum 3D7) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q24B2ZQ2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| D(1A) dopamine receptor (RAT) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 3.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity towards rat Dopamine receptor D1 by [3H]-SCH-23,390 displacement. | J Med Chem 33: 600-7 (1990) BindingDB Entry DOI: 10.7270/Q2XS5TCP | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 7.12E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 7.12E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 8.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2ZS2TZG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 8.48E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q25D8Q6Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Runt-related transcription factor 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 1.78E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2959FWK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mannose-6-phosphate isomerase (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 2.49E+4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description The purpose of this assay is to identify non-competititve inhibitors of human PMI. This is accomplished by using a G6PD- NADPH-coupled assay. In the ... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2CF9NFM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucose-6-phosphate 1-dehydrogenase (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 3.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2V12389 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Procathepsin L (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | >5.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay | Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q20K2704 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Eukaryotic translation initiation factor 4 gamma 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay | Assay Description Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2RN3686 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Polyadenylate-binding protein 1 (Homo sapiens (Human)) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | >6.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2012) BindingDB Entry DOI: 10.7270/Q2V40ST1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q27H1H3W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7) | BDBM29643 ((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PCBioAssay | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q23T9FQ1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
