BindingDB PrimarySearch

Found 25 hits of ic50 for monomerid = 3033
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Protein kinase C beta type (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of PKCbeta				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C gamma type (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of PKCgamma				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of PKCalpha				Proc Natl Acad Sci USA 104: 20523-8 (2007) Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin Curated by ChEMBL					Assay Description Inhibition of PKCalpha				J Biol Chem 282: 15208-16 (2007) Article DOI: 10.1074/jbc.M611907200 BindingDB Entry DOI: 10.7270/Q2NZ87DG
University of Wisconsin Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCalpha by TR-FRET assay				J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9
					More data for this Ligand-Target Pair
Protein kinase C beta type (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin Curated by ChEMBL					Assay Description Inhibition of PKCbeta1				J Biol Chem 282: 15208-16 (2007) Article DOI: 10.1074/jbc.M611907200 BindingDB Entry DOI: 10.7270/Q2NZ87DG
University of Wisconsin Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C beta type (Rattus norvegicus (rat))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Tumor Biology Center					Assay Description The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...				Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C
Tumor Biology Center					More data for this Ligand-Target Pair
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type (Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...)	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro for inhibitory activity against protein kinase C from rat brain				Bioorg Med Chem Lett 3: 1959-1964 (1993) Article DOI: 10.1016/S0960-894X(01)80995-1 BindingDB Entry DOI: 10.7270/Q2QC03DJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKD1 by TR-FRET assay				J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase D1 (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKD1 assessed as HDAC5 neuclear export				J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	446	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of PKCdelta by TR-FRET assay				J Med Chem 53: 5400-21 (2010) Article DOI: 10.1021/jm100075z BindingDB Entry DOI: 10.7270/Q2T153T9
					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tumor Biology Center					Assay Description Tested for inhibition of Myosin light chain kinase from chicken gizzard				Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C
Tumor Biology Center					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Gallus gallus (chicken))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	7.2	30
Tumor Biology Center					Assay Description The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.				Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C
Tumor Biology Center					More data for this Ligand-Target Pair
Myosin light chain kinase, smooth muscle (Gallus gallus (chicken))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)				Bioorg Med Chem Lett 3: 1959-1964 (1993) Article DOI: 10.1016/S0960-894X(01)80995-1 BindingDB Entry DOI: 10.7270/Q2QC03DJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent protein kinase 1 (Bos taurus (bovine))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)				Bioorg Med Chem Lett 3: 1959-1964 (1993) Article DOI: 10.1016/S0960-894X(01)80995-1 BindingDB Entry DOI: 10.7270/Q2QC03DJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-dependent protein kinase 1 (Bos taurus (bovine))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tumor Biology Center					Assay Description The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.				Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C
Tumor Biology Center					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 2 (Mus musculus (mouse))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tumor Biology Center					Assay Description The activity of TPK is measured by its ability to transfer 32P from [gamma-32P]ATP to Poly(Glu,Tyr; 4:l).				Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C
Tumor Biology Center					More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Mus musculus)	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tumor Biology Center					Assay Description Tested for inhibition of general tyrosine-specific protein kinase activity from murine B cell lysate				Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C
Tumor Biology Center					More data for this Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2 (Homo sapiens (Human))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Albert-Ludwigs-Universität Freiburg Curated by ChEMBL					Assay Description Inhibition of human recombinant SIRT2				J Med Chem 49: 7307-16 (2006) Article DOI: 10.1021/jm060118b BindingDB Entry DOI: 10.7270/Q2TQ616P
Albert-Ludwigs-Universität Freiburg Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bos taurus (bovine))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Tumor Biology Center					Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.				Bioorg Med Chem Lett 5: 55-60 (1995) Article DOI: 10.1016/0960-894X(94)00458-R BindingDB Entry DOI: 10.7270/Q2CF9N8C
Tumor Biology Center					More data for this Ligand-Target Pair
cAMP-dependent protein kinase catalytic subunit alpha (Bos taurus (bovine))	BDBM3033 (3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro for inhibitory activity against cAMP-dependent protein kinase from bovine heart (A-kinase)				Bioorg Med Chem Lett 3: 1959-1964 (1993) Article DOI: 10.1016/S0960-894X(01)80995-1 BindingDB Entry DOI: 10.7270/Q2QC03DJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair