BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3 hits of ic50 for monomerid = 444461   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoacylglycerol lipase ABHD6


(Homo sapiens (Human))
BDBM444461
PNG
(US10662159, Example 49)
Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(OCCN3CCCC3)cc2C1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O3/c19-17(20,21)15(18(22,23)24)29-16(27)26-10-12-3-4-14(9-13(12)11-26)28-8-7-25-5-1-2-6-25/h3-4,9,15H,1-2,5-8,10-11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



MAKSCIENTIFIC, LLC

US Patent


Assay Description
ABHD6: Certain compounds were tested for their ABHD6 and dual ABHD6/MGL inhibitory activity, which is expressed as % of inhibition or IC50 values. Th...


US Patent US10662159 (2020)


BindingDB Entry DOI: 10.7270/Q2RB77NZ
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM444461
PNG
(US10662159, Example 49)
Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(OCCN3CCCC3)cc2C1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O3/c19-17(20,21)15(18(22,23)24)29-16(27)26-10-12-3-4-14(9-13(12)11-26)28-8-7-25-5-1-2-6-25/h3-4,9,15H,1-2,5-8,10-11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



MAKSCIENTIFIC, LLC

US Patent


Assay Description
MGL: Compound inhibition of hMGL activity was assessed by a fluorometric assay recently developed in our laboratory (Makriyannis et al WO Patent Appl...


US Patent US10662159 (2020)


BindingDB Entry DOI: 10.7270/Q2RB77NZ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM444461
PNG
(US10662159, Example 49)
Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(OCCN3CCCC3)cc2C1)C(F)(F)F
Show InChI InChI=1S/C18H20F6N2O3/c19-17(20,21)15(18(22,23)24)29-16(27)26-10-12-3-4-14(9-13(12)11-26)28-8-7-25-5-1-2-6-25/h3-4,9,15H,1-2,5-8,10-11H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



MAKSCIENTIFIC, LLC

US Patent


Assay Description
Rat/homo FAAH:Procedure was followed as described for hMGL, except that arachidonoyl-methyl coumarin (was used as fluorigenic substrate. Compounds we...


US Patent US10662159 (2020)


BindingDB Entry DOI: 10.7270/Q2RB77NZ
More data for this
Ligand-Target Pair