Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 8.30 | 5.20 | n/a | n/a | n/a | 7.5 | 25 |
Hebrew University of Jerusalem | Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH... | J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter [G308P] (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 14.5 | 2 | n/a | n/a | n/a | 7.5 | 25 |
Hebrew University of Jerusalem | Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH... | J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter [G308A] (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | >200 | >100 | n/a | n/a | n/a | 7.5 | 25 |
Hebrew University of Jerusalem | Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH... | J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter [P314L] (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | >200 | >100 | n/a | n/a | n/a | 7.5 | 25 |
Hebrew University of Jerusalem | Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH... | J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter [P314T] (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | >200 | >100 | n/a | n/a | n/a | 7.5 | 25 |
Hebrew University of Jerusalem | Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH... | J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter [P314G] (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | >200 | >100 | n/a | n/a | n/a | 7.5 | 25 |
Hebrew University of Jerusalem | Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH... | J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Sodium channel protein type 1/2/3 subunit alpha (Homo sapiens (Human)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea... | J Med Chem 28: 381-8 (1985) BindingDB Entry DOI: 10.7270/Q2Z321T8 | |||||||||||
More data for this Ligand-Target Pair |