Found 2 hits of ic50 for monomerid = 50020073 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50020073
(CHEMBL3287873)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1cc(ccc1F)C(F)(F)F |r,wU:4.3,wD:7.10,(1.78,-14.15,;3.12,-13.38,;3.12,-11.84,;4.45,-14.15,;5.78,-13.38,;5.78,-11.84,;7.12,-11.07,;8.45,-11.84,;8.45,-13.38,;7.12,-14.15,;9.79,-11.07,;9.79,-9.53,;11.12,-8.76,;12.45,-9.53,;12.45,-11.07,;11.12,-11.84,;13.79,-8.76,;15.12,-9.53,;16.45,-8.76,;16.45,-7.22,;17.79,-6.45,;17.79,-4.91,;16.45,-4.14,;15.12,-4.91,;15.12,-6.45,;13.79,-7.22,;19.12,-7.22,;19.12,-8.76,;20.46,-6.45,;21.79,-7.22,;21.79,-8.76,;23.12,-9.53,;24.46,-8.76,;24.46,-7.22,;23.12,-6.45,;23.12,-4.91,;23.12,-11.07,;21.85,-11.97,;24.3,-11.88,;23.12,-12.61,)| Show InChI InChI=1S/C30H28F4N2O4/c31-24-11-10-23(30(32,33)34)17-25(24)35-29(39)36-13-14-40-27-16-22(9-12-26(27)36)21-7-5-20(6-8-21)19-3-1-18(2-4-19)15-28(37)38/h5-12,16-19H,1-4,13-15H2,(H,35,39)(H,37,38)/t18-,19- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50020073
(CHEMBL3287873)Show SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)Nc1cc(ccc1F)C(F)(F)F |r,wU:4.3,wD:7.10,(1.78,-14.15,;3.12,-13.38,;3.12,-11.84,;4.45,-14.15,;5.78,-13.38,;5.78,-11.84,;7.12,-11.07,;8.45,-11.84,;8.45,-13.38,;7.12,-14.15,;9.79,-11.07,;9.79,-9.53,;11.12,-8.76,;12.45,-9.53,;12.45,-11.07,;11.12,-11.84,;13.79,-8.76,;15.12,-9.53,;16.45,-8.76,;16.45,-7.22,;17.79,-6.45,;17.79,-4.91,;16.45,-4.14,;15.12,-4.91,;15.12,-6.45,;13.79,-7.22,;19.12,-7.22,;19.12,-8.76,;20.46,-6.45,;21.79,-7.22,;21.79,-8.76,;23.12,-9.53,;24.46,-8.76,;24.46,-7.22,;23.12,-6.45,;23.12,-4.91,;23.12,-11.07,;21.85,-11.97,;24.3,-11.88,;23.12,-12.61,)| Show InChI InChI=1S/C30H28F4N2O4/c31-24-11-10-23(30(32,33)34)17-25(24)35-29(39)36-13-14-40-27-16-22(9-12-26(27)36)21-7-5-20(6-8-21)19-3-1-18(2-4-19)15-28(37)38/h5-12,16-19H,1-4,13-15H2,(H,35,39)(H,37,38)/t18-,19- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human DGAT1 expressed in Sf9 insect cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-CoA substrate by scintillation counting an... |
ACS Med Chem Lett 5: 544-9 (2014)
Article DOI: 10.1021/ml400527n
BindingDB Entry DOI: 10.7270/Q2KS6T3C |
More data for this
Ligand-Target Pair | |
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