Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50029603 (CHEMBL287919 | L-745337 | L745,337 | N-[6-(2,4-Dif...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development Curated by ChEMBL | Assay Description In vitro inhibition of prostaglandin G/H synthase 2 (COX-2). | J Med Chem 38: 4570-8 (1995) BindingDB Entry DOI: 10.7270/Q23N22D2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50029603 (CHEMBL287919 | L-745337 | L745,337 | N-[6-(2,4-Dif...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description In vitro inhibition of prostaglandin G/H synthase 2 expressed in human osteosarcoma 143 cells | J Med Chem 38: 4897-905 (1996) BindingDB Entry DOI: 10.7270/Q28051PC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50029603 (CHEMBL287919 | L-745337 | L745,337 | N-[6-(2,4-Dif...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cells | Bioorg Med Chem Lett 9: 151-6 (1999) BindingDB Entry DOI: 10.7270/Q21G0KFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50029603 (CHEMBL287919 | L-745337 | L745,337 | N-[6-(2,4-Dif...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Inhibition of Prostaglandin G/H synthase 1 activity in U937 microsomal assay | Bioorg Med Chem Lett 9: 151-6 (1999) BindingDB Entry DOI: 10.7270/Q21G0KFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50029603 (CHEMBL287919 | L-745337 | L745,337 | N-[6-(2,4-Dif...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Inhibition of Prostaglandin G/H synthase 1 activity in U937 microsomal assay | Bioorg Med Chem Lett 9: 151-6 (1999) BindingDB Entry DOI: 10.7270/Q21G0KFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50029603 (CHEMBL287919 | L-745337 | L745,337 | N-[6-(2,4-Dif...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development Curated by ChEMBL | Assay Description In vitro inhibition of prostaglandin G/H synthase 1. | J Med Chem 38: 4570-8 (1995) BindingDB Entry DOI: 10.7270/Q23N22D2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50029603 (CHEMBL287919 | L-745337 | L745,337 | N-[6-(2,4-Dif...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Inhibition of Prostaglandin G/H synthase 1 in human U937 cells | J Med Chem 38: 4897-905 (1996) BindingDB Entry DOI: 10.7270/Q28051PC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50029603 (CHEMBL287919 | L-745337 | L745,337 | N-[6-(2,4-Dif...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL | Assay Description Inhibition of purified recombinant human Prostaglandin G/H synthase 2 | Bioorg Med Chem Lett 9: 151-6 (1999) BindingDB Entry DOI: 10.7270/Q21G0KFM | |||||||||||
More data for this Ligand-Target Pair |