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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DNA (cytosine-5)-methyltransferase 1 (Mus musculus) | BDBM50031317 (CHEMBL3358015) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio... | J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein arginine N-methyltransferase 1 [11-371] (Homo sapiens (Human)) | BDBM50031317 (CHEMBL3358015) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of PRMT1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay | J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase EHMT2 (Homo sapiens (Human)) | BDBM50031317 (CHEMBL3358015) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of G9a (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay | J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase 2A (Homo sapiens (Human)) | BDBM50031317 (CHEMBL3358015) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of MLL1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay | J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase SETD7 (Homo sapiens (Human)) | BDBM50031317 (CHEMBL3358015) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of SET7/9 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay | J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histone-lysine N-methyltransferase SUV39H1 (Homo sapiens (Human)) | BDBM50031317 (CHEMBL3358015) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of SUV39H1 (unknown origin) incubated for 15 mins before addition of biotinylated peptide H3 (1 to 21) and SAM by methylation assay | J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA (cytosine-5)-methyltransferase 3A (Homo sapiens (Human)) | BDBM50031317 (CHEMBL3358015) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of DNMT3A (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting ... | J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DNA (cytosine-5)-methyltransferase 3B (Homo sapiens (Human)) | BDBM50031317 (CHEMBL3358015) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of DNMT3B (unknown origin) incubated for 15 mins before addition of [3H]-SAM and poly(dI-dC).poly(dI-dC) by liquid scintillation counting ... | J Med Chem 57: 9028-41 (2014) Article DOI: 10.1021/jm501134e BindingDB Entry DOI: 10.7270/Q2JD4ZD6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
