BindingDB PrimarySearch

Found 14 hits of ic50 for monomerid = 50112347
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assay				ACS Med Chem Lett 7: 1118-1123 (2016) Article DOI: 10.1021/acsmedchemlett.6b00322 BindingDB Entry DOI: 10.7270/Q2PV6NCH
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 1 [249-545,K299R] (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PAK1 by Z'-LYTE assay				ACS Med Chem Lett 6: 776-81 (2015) Article DOI: 10.1021/acsmedchemlett.5b00102 BindingDB Entry DOI: 10.7270/Q25X2BQS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 2 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	12.8	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 2 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PAK2 by Z'-LYTE assay				ACS Med Chem Lett 6: 776-81 (2015) Article DOI: 10.1021/acsmedchemlett.5b00102 BindingDB Entry DOI: 10.7270/Q25X2BQS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PAK1 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112220 BindingDB Entry DOI: 10.7270/Q20C50JG
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 3 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PAK3 by Z'-LYTE assay				ACS Med Chem Lett 6: 776-81 (2015) Article DOI: 10.1021/acsmedchemlett.5b00102 BindingDB Entry DOI: 10.7270/Q25X2BQS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 2 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PAK2 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112220 BindingDB Entry DOI: 10.7270/Q20C50JG
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 3 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	19.3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 3 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PAK3 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112220 BindingDB Entry DOI: 10.7270/Q20C50JG
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PAK1 (unknown origin)				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127355 BindingDB Entry DOI: 10.7270/Q2PC363K
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of PAK1 phosphorylation in human MCF10A cells				ACS Med Chem Lett 7: 1118-1123 (2016) Article DOI: 10.1021/acsmedchemlett.6b00322 BindingDB Entry DOI: 10.7270/Q2PV6NCH
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...				J Biol Chem 288: 29105-14 (2013) Article DOI: 10.1074/jbc.M113.510933 BindingDB Entry DOI: 10.7270/Q2B27T4S
The Scripps Research Institute					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50112347 (CHEMBL3609327 \| FRAX597) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human PAK4 by Z'-LYTE assay				ACS Med Chem Lett 6: 776-81 (2015) Article DOI: 10.1021/acsmedchemlett.5b00102 BindingDB Entry DOI: 10.7270/Q25X2BQS
					More data for this Ligand-Target Pair