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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50162160 (1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of vascular endothelial growth factor receptor 2 | J Med Chem 48: 1359-66 (2005) Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50162160 (1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Kirin Brewery Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay | J Med Chem 48: 1359-66 (2005) Article DOI: 10.1021/jm030427r BindingDB Entry DOI: 10.7270/Q23J3CG1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50162160 (1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of EGFR expressed in DHER14 cells by western blot analysis | Bioorg Med Chem 16: 4242-51 (2008) Article DOI: 10.1016/j.bmc.2008.02.081 BindingDB Entry DOI: 10.7270/Q2B85903 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human)) | BDBM50162160 (1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >500 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of Her2 expressed in CSH12 cells by western blot analysis | Bioorg Med Chem 16: 4242-51 (2008) Article DOI: 10.1016/j.bmc.2008.02.081 BindingDB Entry DOI: 10.7270/Q2B85903 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM50162160 (1-(2,4-Difluoro-phenyl)-3-[4-(6,7-dimethoxy-quinol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hadassah Hebrew University Hospital Curated by ChEMBL | Assay Description Inhibition of IGF1R by ELISA | Bioorg Med Chem 16: 4242-51 (2008) Article DOI: 10.1016/j.bmc.2008.02.081 BindingDB Entry DOI: 10.7270/Q2B85903 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
