Found 4 hits of ic50 for monomerid = 50215758 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50215758
(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)Show SMILES Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 Show InChI InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cKit by FRET assay |
Bioorg Med Chem Lett 17: 4378-81 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50215758
(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)Show SMILES Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 Show InChI InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cKit by FRET assay |
Bioorg Med Chem Lett 17: 4378-81 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50215758
(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)Show SMILES Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 Show InChI InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 634 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibition of b-Raf |
Bioorg Med Chem Lett 17: 4378-81 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50215758
(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)Show SMILES Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 Show InChI InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 634 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Research Center
Curated by ChEMBL
| Assay Description Inhibition of b-Raf |
Bioorg Med Chem Lett 17: 4378-81 (2007)
Article DOI: 10.1016/j.bmcl.2007.02.075 BindingDB Entry DOI: 10.7270/Q28K78S7 |
More data for this Ligand-Target Pair | |