Found 8 hits of ic50 for monomerid = 50268321 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50268321
(6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)...)Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| Show InChI InChI=1S/C24H28N2O4S/c1-31(28,29)19-7-8-22-18(15-19)9-10-24(30-22)11-13-26(14-12-24)23(27)25-21-16-20(21)17-5-3-2-4-6-17/h2-8,15,20-21H,9-14,16H2,1H3,(H,25,27)/t20-,21+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human soluble epoxide hydrolase |
Bioorg Med Chem Lett 19: 3398-404 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.036
BindingDB Entry DOI: 10.7270/Q20C4VP7 |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Homo sapiens (Human)) | BDBM50268321
(6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)...)Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| Show InChI InChI=1S/C24H28N2O4S/c1-31(28,29)19-7-8-22-18(15-19)9-10-24(30-22)11-13-26(14-12-24)23(27)25-21-16-20(21)17-5-3-2-4-6-17/h2-8,15,20-21H,9-14,16H2,1H3,(H,25,27)/t20-,21+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human soluble epoxide hydrolase |
Bioorg Med Chem Lett 19: 3398-404 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.036
BindingDB Entry DOI: 10.7270/Q20C4VP7 |
More data for this
Ligand-Target Pair | |
Bifunctional epoxide hydrolase 2
(Rattus norvegicus) | BDBM50268321
(6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)...)Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| Show InChI InChI=1S/C24H28N2O4S/c1-31(28,29)19-7-8-22-18(15-19)9-10-24(30-22)11-13-26(14-12-24)23(27)25-21-16-20(21)17-5-3-2-4-6-17/h2-8,15,20-21H,9-14,16H2,1H3,(H,25,27)/t20-,21+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of rat soluble epoxide hydrolase |
Bioorg Med Chem Lett 19: 3398-404 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.036
BindingDB Entry DOI: 10.7270/Q20C4VP7 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50268321
(6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)...)Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| Show InChI InChI=1S/C24H28N2O4S/c1-31(28,29)19-7-8-22-18(15-19)9-10-24(30-22)11-13-26(14-12-24)23(27)25-21-16-20(21)17-5-3-2-4-6-17/h2-8,15,20-21H,9-14,16H2,1H3,(H,25,27)/t20-,21+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of CYP2C9 |
Bioorg Med Chem Lett 19: 3398-404 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.036
BindingDB Entry DOI: 10.7270/Q20C4VP7 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50268321
(6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)...)Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| Show InChI InChI=1S/C24H28N2O4S/c1-31(28,29)19-7-8-22-18(15-19)9-10-24(30-22)11-13-26(14-12-24)23(27)25-21-16-20(21)17-5-3-2-4-6-17/h2-8,15,20-21H,9-14,16H2,1H3,(H,25,27)/t20-,21+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 |
Bioorg Med Chem Lett 19: 3398-404 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.036
BindingDB Entry DOI: 10.7270/Q20C4VP7 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50268321
(6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)...)Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| Show InChI InChI=1S/C24H28N2O4S/c1-31(28,29)19-7-8-22-18(15-19)9-10-24(30-22)11-13-26(14-12-24)23(27)25-21-16-20(21)17-5-3-2-4-6-17/h2-8,15,20-21H,9-14,16H2,1H3,(H,25,27)/t20-,21+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 |
Bioorg Med Chem Lett 19: 3398-404 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.036
BindingDB Entry DOI: 10.7270/Q20C4VP7 |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50268321
(6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)...)Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| Show InChI InChI=1S/C24H28N2O4S/c1-31(28,29)19-7-8-22-18(15-19)9-10-24(30-22)11-13-26(14-12-24)23(27)25-21-16-20(21)17-5-3-2-4-6-17/h2-8,15,20-21H,9-14,16H2,1H3,(H,25,27)/t20-,21+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Voltage-gated sodium channel subunit alpha Nav1.5 |
Bioorg Med Chem Lett 19: 3398-404 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.036
BindingDB Entry DOI: 10.7270/Q20C4VP7 |
More data for this
Ligand-Target Pair | |
Epoxide hydrolase 1
(Homo sapiens (Human)) | BDBM50268321
(6-(methylsulfonyl)-N-((trans)-2-phenylcyclopropyl)...)Show SMILES CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)N[C@H]3C[C@@H]3c3ccccc3)CCc2c1 |r| Show InChI InChI=1S/C24H28N2O4S/c1-31(28,29)19-7-8-22-18(15-19)9-10-24(30-22)11-13-26(14-12-24)23(27)25-21-16-20(21)17-5-3-2-4-6-17/h2-8,15,20-21H,9-14,16H2,1H3,(H,25,27)/t20-,21+/m1/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human microsomal epoxide hydrolase |
Bioorg Med Chem Lett 19: 3398-404 (2009)
Article DOI: 10.1016/j.bmcl.2009.05.036
BindingDB Entry DOI: 10.7270/Q20C4VP7 |
More data for this
Ligand-Target Pair | |
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