Found 7 hits of ic50 for monomerid = 50279593 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50279593
(CHEMBL4168811)Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)CN5CCOCC5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H30N4O5/c1-39-31(38)22-8-10-24-25(17-22)33-30(37)28(24)29(21-5-3-2-4-6-21)32-23-9-7-20-11-12-35(26(20)18-23)27(36)19-34-13-15-40-16-14-34/h2-10,17-18,32H,11-16,19H2,1H3,(H,33,37)/b29-28- | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant RET (unknown origin) by off-chip mobility shift assay |
ACS Med Chem Lett 8: 1142-1147 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50279593
(CHEMBL4168811)Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)CN5CCOCC5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H30N4O5/c1-39-31(38)22-8-10-24-25(17-22)33-30(37)28(24)29(21-5-3-2-4-6-21)32-23-9-7-20-11-12-35(26(20)18-23)27(36)19-34-13-15-40-16-14-34/h2-10,17-18,32H,11-16,19H2,1H3,(H,33,37)/b29-28- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant c-KIT (unknown origin) by off-chip mobility shift assay |
ACS Med Chem Lett 8: 1142-1147 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50279593
(CHEMBL4168811)Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)CN5CCOCC5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H30N4O5/c1-39-31(38)22-8-10-24-25(17-22)33-30(37)28(24)29(21-5-3-2-4-6-21)32-23-9-7-20-11-12-35(26(20)18-23)27(36)19-34-13-15-40-16-14-34/h2-10,17-18,32H,11-16,19H2,1H3,(H,33,37)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description H1-antihistamine activity on guinea pig ileum |
ACS Med Chem Lett 8: 1142-1147 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50279593
(CHEMBL4168811)Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)CN5CCOCC5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H30N4O5/c1-39-31(38)22-8-10-24-25(17-22)33-30(37)28(24)29(21-5-3-2-4-6-21)32-23-9-7-20-11-12-35(26(20)18-23)27(36)19-34-13-15-40-16-14-34/h2-10,17-18,32H,11-16,19H2,1H3,(H,33,37)/b29-28- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of human ERG |
ACS Med Chem Lett 8: 1142-1147 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Mus musculus (mouse)) | BDBM50279593
(CHEMBL4168811)Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)CN5CCOCC5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H30N4O5/c1-39-31(38)22-8-10-24-25(17-22)33-30(37)28(24)29(21-5-3-2-4-6-21)32-23-9-7-20-11-12-35(26(20)18-23)27(36)19-34-13-15-40-16-14-34/h2-10,17-18,32H,11-16,19H2,1H3,(H,33,37)/b29-28- | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of PDGFR in mouse NIH/3T3 cells assessed as reduction in recombinant human PDGF-BB-induced cell proliferation after 42 hrs by cell titer 9... |
ACS Med Chem Lett 8: 1142-1147 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279593
(CHEMBL4168811)Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)CN5CCOCC5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H30N4O5/c1-39-31(38)22-8-10-24-25(17-22)33-30(37)28(24)29(21-5-3-2-4-6-21)32-23-9-7-20-11-12-35(26(20)18-23)27(36)19-34-13-15-40-16-14-34/h2-10,17-18,32H,11-16,19H2,1H3,(H,33,37)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant VEGFR2 (unknown origin) by off-chip mobility shift assay |
ACS Med Chem Lett 8: 1142-1147 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279593
(CHEMBL4168811)Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)CN5CCOCC5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H30N4O5/c1-39-31(38)22-8-10-24-25(17-22)33-30(37)28(24)29(21-5-3-2-4-6-21)32-23-9-7-20-11-12-35(26(20)18-23)27(36)19-34-13-15-40-16-14-34/h2-10,17-18,32H,11-16,19H2,1H3,(H,33,37)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of recombinant FGFR1 (unknown origin) by off-chip mobility shift assay |
ACS Med Chem Lett 8: 1142-1147 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND |
More data for this Ligand-Target Pair | |