Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity protein kinase CLK1 (Mus musculus) | BDBM50312212 ((5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£? de Rennes 1 Curated by ChEMBL | Assay Description Inhibition of mouse recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate | J Med Chem 54: 4172-86 (2011) Article DOI: 10.1021/jm200274d BindingDB Entry DOI: 10.7270/Q27D2VHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Homo sapiens (Human)) | BDBM50312212 ((5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2...) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£? de Rennes 1 Curated by ChEMBL | Assay Description Inhibition of human recombinant GST-tagged DYRK2 using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting | J Med Chem 54: 4172-86 (2011) Article DOI: 10.1021/jm200274d BindingDB Entry DOI: 10.7270/Q27D2VHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (RAT) | BDBM50312212 ((5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£? de Rennes 1 Curated by ChEMBL | Assay Description Inhibition of rat recombinant GST-tagged DYRK1A using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting | J Med Chem 54: 4172-86 (2011) Article DOI: 10.1021/jm200274d BindingDB Entry DOI: 10.7270/Q27D2VHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human)) | BDBM50312212 ((5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£? de Rennes 1 Curated by ChEMBL | Assay Description Inhibition of human recombinant CDK5/p25 | J Med Chem 54: 4172-86 (2011) Article DOI: 10.1021/jm200274d BindingDB Entry DOI: 10.7270/Q27D2VHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM50312212 ((5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£? de Rennes 1 Curated by ChEMBL | Assay Description Inhibition of human recombinant Pim1 | J Med Chem 54: 4172-86 (2011) Article DOI: 10.1021/jm200274d BindingDB Entry DOI: 10.7270/Q27D2VHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase CLK3 (Mus musculus) | BDBM50312212 ((5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£? de Rennes 1 Curated by ChEMBL | Assay Description Inhibition of mouse recombinant GST-tagged CLK3 using GRSRSRSRSRSR as substrate | J Med Chem 54: 4172-86 (2011) Article DOI: 10.1021/jm200274d BindingDB Entry DOI: 10.7270/Q27D2VHR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 5 activator 1 (Homo sapiens (Human)) | BDBM50312212 ((5Z)-5-[(1,3-benzodioxo-5-yl)methylene]-3-methyl-2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human CDK5/p25 | Eur J Med Chem 45: 805-10 (2010) Article DOI: 10.1016/j.ejmech.2009.10.009 BindingDB Entry DOI: 10.7270/Q29023XH | |||||||||||
More data for this Ligand-Target Pair |