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Target
Sequence
Name
&
Ki
IC50
Kd
EC50
Rate constants
ΔG°
ΔH°
-TΔS°
pH (Enzymatic Assay)
pH (ITC)
Substrate or Competitor
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/
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Target Names &
Ki
IC50
Kd
EC50
ΔG°
ΔH°
-TΔS°
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Compile Data Set for Download or QSAR
Found
4
hits of ic50 for monomerid = 50382317
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
TGF-beta receptor type-1
(Homo sapiens (Human))
BDBM50382317
(CHEMBL2024684)
Show SMILES
Cc1cccc(n1)-n1nccc1-c1ccc2ncn(C)c(=O)c2c1
Show InChI
InChI=1S/C18H15N5O/c1-12-4-3-5-17(21-12)23-16(8-9-20-23)13-6-7-15-14(10-13)18(24)22(2)11-19-15/h3-11H,1-2H3
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
13
n/a
n/a
n/a
n/a
n/a
n/a
Pfizer Inc.
Curated by
ChEMBL
Assay Description
Inhibition of ALK5
Bioorg Med Chem Lett
22:
3392
-
7
(2012)
Article DOI:
10.1016/j.bmcl.2012.04.013
BindingDB Entry DOI:
10.7270/Q2QC04H9
More data for this
Ligand-Target Pair
Activin receptor type-1B
(Homo sapiens (Human))
BDBM50382317
(CHEMBL2024684)
Show SMILES
Cc1cccc(n1)-n1nccc1-c1ccc2ncn(C)c(=O)c2c1
Show InChI
InChI=1S/C18H15N5O/c1-12-4-3-5-17(21-12)23-16(8-9-20-23)13-6-7-15-14(10-13)18(24)22(2)11-19-15/h3-11H,1-2H3
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
59
n/a
n/a
n/a
n/a
n/a
n/a
Pfizer Inc.
Curated by
ChEMBL
Assay Description
Inhibition of ALK4
Bioorg Med Chem Lett
22:
3392
-
7
(2012)
Article DOI:
10.1016/j.bmcl.2012.04.013
BindingDB Entry DOI:
10.7270/Q2QC04H9
More data for this
Ligand-Target Pair
TGF-beta receptor type-1
(Mus musculus)
BDBM50382317
(CHEMBL2024684)
Show SMILES
Cc1cccc(n1)-n1nccc1-c1ccc2ncn(C)c(=O)c2c1
Show InChI
InChI=1S/C18H15N5O/c1-12-4-3-5-17(21-12)23-16(8-9-20-23)13-6-7-15-14(10-13)18(24)22(2)11-19-15/h3-11H,1-2H3
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
211
n/a
n/a
n/a
n/a
n/a
n/a
Pfizer Inc.
Curated by
ChEMBL
Assay Description
Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assay
Bioorg Med Chem Lett
22:
3392
-
7
(2012)
Article DOI:
10.1016/j.bmcl.2012.04.013
BindingDB Entry DOI:
10.7270/Q2QC04H9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase receptor R3
(Homo sapiens (Human))
BDBM50382317
(CHEMBL2024684)
Show SMILES
Cc1cccc(n1)-n1nccc1-c1ccc2ncn(C)c(=O)c2c1
Show InChI
InChI=1S/C18H15N5O/c1-12-4-3-5-17(21-12)23-16(8-9-20-23)13-6-7-15-14(10-13)18(24)22(2)11-19-15/h3-11H,1-2H3
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
Article
PubMed
n/a
n/a
>5.00E+3
n/a
n/a
n/a
n/a
n/a
n/a
Pfizer Inc.
Curated by
ChEMBL
Assay Description
Inhibition of ALK1
Bioorg Med Chem Lett
22:
3392
-
7
(2012)
Article DOI:
10.1016/j.bmcl.2012.04.013
BindingDB Entry DOI:
10.7270/Q2QC04H9
More data for this
Ligand-Target Pair
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