Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM50005711 (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 12.1 | n/a | n/a | n/a | 8.0 | n/a |
Genentech, Inc. | Assay Description Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD... | J Biol Chem 288: 26926-43 (2013) Article DOI: 10.1074/jbc.M113.490706 BindingDB Entry DOI: 10.7270/Q2KK99MZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM50005711 (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 15.3 | n/a | n/a | n/a | 8.0 | n/a |
Genentech, Inc. | Assay Description Specifically, the experiments were conducted in black 384-well polypropylene plates (Corning Glass) in a 15-ul reaction volume consisting of 11 nM HD... | J Biol Chem 288: 26926-43 (2013) Article DOI: 10.1074/jbc.M113.490706 BindingDB Entry DOI: 10.7270/Q2KK99MZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50005711 (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a |
University of Bayreuth Curated by ChEMBL | Assay Description Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of ADP-ribose... | J Med Chem 61: 10922-10928 (2018) Article DOI: 10.1021/acs.jmedchem.8b01455 BindingDB Entry DOI: 10.7270/Q2GQ71GJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50005711 (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a |
University of Bayreuth Curated by ChEMBL | Assay Description Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of ADP-ribose... | J Med Chem 61: 10922-10928 (2018) Article DOI: 10.1021/acs.jmedchem.8b01455 BindingDB Entry DOI: 10.7270/Q2GQ71GJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50005711 (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 2.27E+5 | n/a | n/a | n/a | n/a | n/a |
University of Bayreuth Curated by ChEMBL | Assay Description Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins by fluorescence-based SDS... | J Med Chem 61: 10922-10928 (2018) Article DOI: 10.1021/acs.jmedchem.8b01455 BindingDB Entry DOI: 10.7270/Q2GQ71GJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
NAD-dependent protein deacylase sirtuin-6 (Homo sapiens (Human)) | BDBM50005711 (CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 4.45E+5 | n/a | n/a | n/a | n/a | n/a |
University of Bayreuth Curated by ChEMBL | Assay Description Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of NAM by flu... | J Med Chem 61: 10922-10928 (2018) Article DOI: 10.1021/acs.jmedchem.8b01455 BindingDB Entry DOI: 10.7270/Q2GQ71GJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |