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Compile Data Set for Download or QSAR

Found 2 hits of ki for monomerid = 493825   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM493825
PNG
(US10988459, Example 37)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncn3ccc(cc23)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C19H15F3N4O3/c1-25-13-4-2-3-5-15(13)29-9-12(18(25)28)24-17(27)16-14-8-11(19(20,21)22)6-7-26(14)10-23-16/h2-8,10,12H,9H2,1H3,(H,24,27)/t12-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant human His/GST-tagged RIPK1 (2 to 257 residues) expressed in insect expression system incubated for 2 hrs by fluorescence po...


Citation and Details

Article DOI: 10.1016/j.bmcl.2019.04.014
BindingDB Entry DOI: 10.7270/Q22J6GG3
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 [2-375]


(Homo sapiens (Human))
BDBM493825
PNG
(US10988459, Example 37)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncn3ccc(cc23)C(F)(F)F)C1=O |r|
Show InChI InChI=1S/C19H15F3N4O3/c1-25-13-4-2-3-5-15(13)29-9-12(18(25)28)24-17(27)16-14-8-11(19(20,21)22)6-7-26(14)10-23-16/h2-8,10,12H,9H2,1H3,(H,24,27)/t12-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.08n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is monitored using...


US Patent US10988459 (2021)


BindingDB Entry DOI: 10.7270/Q2Z89GJF
More data for this
Ligand-Target Pair