BDBM493825 US10988459, Example 37

SMILES: CN1c2ccccc2OC[C@H](NC(=O)c2ncn3ccc(cc23)C(F)(F)F)C1=O

InChI Key: InChIKey=NHKZCXJIIYRGRS-LBPRGKRZSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493825   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM493825 (US10988459, Example 37) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncn3ccc(cc23)C(F)(F)F)C1=O |r| Show InChI InChI=1S/C19H15F3N4O3/c1-25-13-4-2-3-5-15(13)29-9-12(18(25)28)24-17(27)16-14-8-11(19(20,21)22)6-7-26(14)10-23-16/h2-8,10,12H,9H2,1H3,(H,24,27)/t12-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 1 [2-375] (Homo sapiens (Human))	BDBM493825 (US10988459, Example 37) Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncn3ccc(cc23)C(F)(F)F)C1=O |r| Show InChI InChI=1S/C19H15F3N4O3/c1-25-13-4-2-3-5-15(13)29-9-12(18(25)28)24-17(27)16-14-8-11(19(20,21)22)6-7-26(14)10-23-16/h2-8,10,12H,9H2,1H3,(H,24,27)/t12-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.08	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is monitored using...				US Patent US10988459 (2021)
					More data for this Ligand-Target Pair